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Generation and Characterization of Stable α-Synuclein Oligomers
Alpha-synuclein oligomers are linked to the pathogenesis of Parkinson’s disease and related neurodegenerative diseases. In this chapter, we present a method to generate kinetically stable α-synuclein oligomers...
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Article
Open AccessImmune cells lacking Y chromosome show dysregulation of autosomal gene expression
Epidemiological investigations show that mosaic loss of chromosome Y (LOY) in leukocytes is associated with earlier mortality and morbidity from many diseases in men. LOY is the most common acquired mutation a...
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Article
Open AccessMutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia
Most dementia disorders have a clear genetic background and a number of disease genes have been identified. Mutations in the tau gene (MAPT) lead to frontotemporal dementia (FTD), whereas mutations in the genes f...