10 Result(s)

Article

Correction: Triple MAPK inhibition salvaged a relapsed post-BCMA CAR-T cell therapy multiple myeloma patient with a BRAF V600E subclonal mutation

Muhammad Elnaggar, Sarita Agte, Paula Restrepo… in Journal of Hematology & Oncology (2023)

Article

Publisher Correction: A pipeline for malignancy and therapy agnostic assessment of cancer drug response using cell mass measurements

Robert J. Kimmerling, Mark M. Stevens, Selim Olcum… in Communications Biology (2023)

Article

A pipeline for malignancy and therapy agnostic assessment of cancer drug response using cell mass measurements

Functional precision medicine offers a promising complement to genomics-based cancer therapy guidance by testing drug efficacy directly on a patient’s tumor cells. Here, we describe a workflow that utilizes si...

Robert J. Kimmerling, Mark M. Stevens, Selim Olcum… in Communications Biology (2022)

Article

Triple MAPK inhibition salvaged a relapsed post-BCMA CAR-T cell therapy multiple myeloma patient with a BRAF V600E subclonal mutation

Multiple Myeloma (MM) is a progressive plasma cell neoplasm characterized by heterogeneous clonal expansion. Despite promising response rates achieved with anti-BCMA CAR-T cell therapy, patients may still rela...

Muhammad Elnaggar, Sarita Agte, Paula Restrepo… in Journal of Hematology & Oncology (2022)

Article

Transmission of Metarhizium anisopliae and Beauveria bassiana to adults of Kuschelorhynchus macadamiae (Coleoptera: Curculionidae) from infected adults and conidiated cadavers

Kuschelorhynchus macadamiae is a major pest of macadamias in Australia, causing yield losses of up to 15%. Our previous studies have shown the weevil is susceptible to Beauveria bassiana and Metarhizium anisoplia...

Kim Khuy Khun, Gavin J. Ash, Mark M. Stevens, Ruth K. Huwer… in Scientific Reports (2021)

Article

Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Sungmin Son, Mark M. Stevens, Hui **ao Chao, Carson Thoreen… in Scientific Reports (2020)

Article

Linking single-cell measurements of mass, growth rate, and gene expression

Mass and growth rate are highly integrative measures of cell physiology not discernable via genomic measurements. Here, we introduce a microfluidic platform enabling direct measurement of single-cell mass and ...

Robert J. Kimmerling, Sanjay M. Prakadan, Alejandro J. Gupta… in Genome Biology (2018)

Article

Microfluidic active loading of single cells enables analysis of complex clinical specimens

A fundamental trade-off between flow rate and measurement precision limits performance of many single-cell detection strategies, especially for applications that require biophysical measurements from living ce...

Nicholas L. Calistri, Robert J. Kimmerling, Seth W. Malinowski… in Nature Communications (2018)

Article

Determining therapeutic susceptibility in multiple myeloma by single-cell mass accumulation

Multiple myeloma (MM) has benefited from significant advancements in treatment that have improved outcomes and reduced morbidity. However, the disease remains incurable and is characterized by high rates of dr...

Arif E. Cetin, Mark M. Stevens, Nicholas L. Calistri… in Nature Communications (2017)

Article

Cooperative nutrient accumulation sustains growth of mammalian cells

The coordination of metabolic processes to allow increased nutrient uptake and utilization for macromolecular synthesis is central for cell growth. Although studies of bulk cell populations have revealed impor...

Sungmin Son, Mark M. Stevens, Hui **ao Chao, Carson Thoreen… in Scientific Reports (2015)