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  1. No Access

    Article

    Using proteomics to identify ubiquitin ligase–substrate pairs: how novel methods may unveil therapeutic targets for neurodegenerative diseases

    Ubiquitin ligases play an integral role in fine-tuning signaling cascades necessary for normal cell function. Aberrant regulation of ubiquitin ligases has been implicated in several neurodegenerative diseases,...

    Stephanie L. Rayner, Marco Morsch, Mark P. Molloy… in Cellular and Molecular Life Sciences (2019)

  2. No Access

    Article

    Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of develo** zebrafish

    Aurora kinase B (AurkB) is a serine/threonine protein kinase with a well-characterised role in orchestrating cell division and cytokinesis, and is prominently expressed in healthy proliferating and cancerous c...

    Serene S. L. Gwee, Rowan A. W. Radford… in Cellular and Molecular Life Sciences (2018)

  3. No Access

    Article

    Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

    Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders that have common molecular and pathogenic characteristics, such as aberrant accumulation and ubiquity...

    Albert Lee, Stephanie L. Rayner, Serene S. L. Gwee… in Cellular and Molecular Life Sciences (2018)