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Extracellular amyloid formation and associated pathology in neural grafts
Amyloid precursor protein (APP) processing and the generation of β-amyloid peptide (Aβ) are important in the pathogenesis of Alzheimer's disease. Although this has been studied extensively at the molecular and...
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The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
The amyloid cascade hypothesis posits that the deposition of the amyloid-β peptide in the brain parenchyma is a crucial step in Alzheimer's disease (AD). This ...