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  1. No Access

    Article

    The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

  2. The amyloid cascade hypothesis posits that the deposition of the amyloid-β peptide in the brain parenchyma is a crucial step in Alzheimer's disease (AD). This ...

    3. Eric Karran, Marc Mercken, Bart De Strooper in Nature Reviews Drug Discovery (2011)

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    Article

    Extracellular amyloid formation and associated pathology in neural grafts

    Amyloid precursor protein (APP) processing and the generation of β-amyloid peptide (Aβ) are important in the pathogenesis of Alzheimer's disease. Although this has been studied extensively at the molecular and...

    Melanie Meyer-Luehmann, Martina Stalder, Martin C. Herzig… in Nature Neuroscience (2003)