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Article
The genetic profile of bone marrow transplant patients in different samples of forensic interest
Humans constantly lose epithelial cells, and these biological traces are frequently studied in the context of criminal investigations. The objective of this work was to examine the genetic profile in samples o...
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Article
Indel analysis by droplet digital PCR: a sensitive method for DNA mixture detection and chimerism analysis
Several methods have been developed to determinate genetic profiles from a mixed samples and chimerism analysis in transplanted patients. The aim of this study was to explore the effectiveness of using the dro...
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Article
Development and validation of a multiplex reaction analyzing eight miniSTRs of the X chromosome for identity and kinship testing with degraded DNA
We report the development of an effective system for analyzing X chromosome-linked mini short tandem repeat loci with reduced-size amplicons (less than 220 bp), useful for analyzing highly degraded DNA samples...
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Article
miRNA analysis in vitreous humor to determine the time of death: a proof-of-concept pilot study
We hypothesized that miRNAs present in vitreous humor could be a sort of “biological black box,” storing information about physiological and environmental circumstances at death. As a proof of concept, we anal...
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Article
Forensic efficiency of microsatellites and single nucleotide polymorphisms on the X chromosome
Polymorphisms located on the X chromosome are being increasingly used in forensic studies. However, they have not been studied as extensively as the autosomal and Y-linked polymorphisms. Therefore, we planned ...
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Article
Spanish population data and forensic usefulness of a novel Y-STR set (DYS437, DYS438, DYS439, DYS460, DYS461, GATA A10, GATA C4, GATA H4)
DNA ty** of 8 recently described STRs on the Y chromosome was carried out by means of 2 multiplex amplification reactions for 134 unrelated males from Cantabria, a region in northern Spain. Multiplex 1 inclu...
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Article
Significance of micro-geographical population structure in forensic cases: a bayesian exploration
We studied the influence of population structure at the microgeographical level on the analysis of forensic cases. A total of nine autosomal STRs and seven Y-STRs were analyzed in the general mixed population ...
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Article
Sequence structure and population data of two X-linked markers: DXS7423 and DXS8377
DXS7423 and DXS8377 are two microsatellite markers located in the q28 band of chromosome X. We developed a protocol to amplify both markers in a single reaction, sequenced the most common alleles and studied ...
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Article
The prosecutor's and defendant's Bayesian nomograms
Two nomograms to calculate posterior odds and probabilities in forensic cases according to Bayes' theorem are presented.