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  1. No Access

    Article

    Osterix and RUNX2 are Transcriptional Regulators of Sclerostin in Human Bone

    Sclerostin, encoded by the SOST gene, works as an inhibitor of the Wnt pathway and therefore is an important regulator of bone homeostasis. Due to its potent action as an inhibitor of bone formation, blocking scl...

    Flor M. Pérez-Campo, Ana Santurtún, Carmen García-Ibarbia… in Calcified Tissue International (2016)

  2. No Access

    Article

    Exon array analysis reveals genetic heterogeneity in atypical femoral fractures. A pilot study

    Atraumatic subtrochanteric and diaphyseal (atypical) femoral fractures are a rare, but important adverse event in patients treated with potent anti-resortive agents. The mechanisms involved are unknown and par...

    Isabel Pérez-Núñez, José L. Pérez-Castrillón… in Molecular and Cellular Biochemistry (2015)

  3. No Access

    Article

    A Sclerostin Super-Producer Cell Line Derived from the Human Cell Line SaOS-2: A New Tool for the Study of the Molecular Mechanisms Driving Sclerostin Expression

    Sclerostin, the product of the SOST gene, is a key regulator of bone homeostasis. Sclerostin interferes with the Wnt signalling pathway and, therefore, has a negative effect on bone formation. Although the imp...

    Flor M. Pérez-Campo, Carolina Sañudo, Jesús Delgado-Calle… in Calcified Tissue International (2014)