28 Result(s)

Article

The potential of high-order features of routine blood test in predicting the prognosis of non-small cell lung cancer

Numerous studies have demonstrated that the high-order features (HOFs) of blood test data can be used to predict the prognosis of patients with different types of cancer. Although the majority of blood HOFs ca...

Li** Luo, Yubo Tan, Shixuan Zhao, Man Yang, Yurou Che, Kezhen Li, Jieke Liu… in BMC Cancer (2023)

Article

Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis

Chemoresistance is the main reason for the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Thus, there is an urgent need to screen out new targets and compounds to reverse chemotherapeutic resistance.

Tianxing Zhou, Yongjie **e, Xupeng Hou… in Journal of Experimental & Clinical Cancer … (2023)

Article

Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids

Horseshoe bats host numerous SARS-related coronaviruses without overt disease signs. Bat intestinal organoids, a unique model of bat intestinal epithelium, allow direct comparison with human intestinal organoi...

**aojuan Liu, Cun Li, Zhixin Wan, Man Chun Chiu… in Signal Transduction and Targeted Therapy (2022)

Article

Correction: Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer progression by cis-regulating the nearby gene MK5 and acting as a let-7f-1-3p sponge

Ting Yang, Wei-Cong Chen, Pei-Cong Shi… in Journal of Experimental & Clinical Cancer … (2022)

Article

Utility of whole exome sequencing analysis in differentiating intrapulmonary metastatic multiple ground-glass nodules (GGNs) from multiple primary GGNs

Clinical evidence of metastasis with ground-glass nodules (GGNs) has been reported, including pulmonary metastasis and distant metastasis. However, the clonal relationships of multiple GGNs at the genetic leve...

Dong Zhou, Quan-**ng Liu, Man-yuan Li… in International Journal of Clinical Oncology (2022)

Article

BuFei**aoJiYin ameliorates the NLRP3 inflammation response and gut microbiota in mice with lung cancer companied with Qi-yin deficiency

NLRP3 inflammasome responses and gut microbiota have been shown an important role in lung cancer, however, the relationship between gut microbiota and NLRP3 inflammasome responses in lung cancer with Qi-yin de...

Rui-yuan Jiang, Ting Wang, Qiao-yu Lan, Yan-chun Qin… in Cancer Cell International (2022)

Article

Two divergent haplotypes from a highly heterozygous lychee genome suggest independent domestication events for early and late-maturing cultivars

Lychee is an exotic tropical fruit with a distinct flavor. The genome of cultivar ‘Feizixiao’ was assembled into 15 pseudochromosomes, totaling ~470 Mb. High heterozygosity (2.27%) resulted in two complete hap...

Guibing Hu, Junting Feng, Xu **ang, Jiabao Wang, Jarkko Salojärvi… in Nature Genetics (2022)

Article

Survival-associated N⁶-adenosine methyltransferase signatures in lung squamous cell carcinoma and clinical verification

N⁶-methyladenine (m⁶A) is the most common modification of mRNA and IncRNA in higher organisms. m⁶A has been confirmed to be related to the formation and progression of tumors and m⁶A-related genes can be used as ...

Jialin Qu, Li Wang, Man Jiang, Zhimin Wei, Guangming Fu, **aochun Zhang in BMC Cancer (2021)

Article

Downregulated ZNF132 predicts unfavorable outcomes in breast Cancer via Hypermethylation modification

An important mechanism that promoter methylation-mediated gene silencing for gene inactivation is identified in human tumorigenesis. Methylated genes have been found in breast cancer (BC) and beneficial biomar...

Zhao Liu, Jiaxin Liu, Ruimiao Liu, Man Xue, Weifan Zhang, **nhui Zhao… in BMC Cancer (2021)

Article

Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians

The clinical utility of personal genomic information in identifying individuals at increased risks for dyslipidemia and cardiovascular diseases remains unclear.

Claudia H. T. Tam, Cadmon K. P. Lim, Andrea O. Y. Luk, Alex C. W. Ng… in Genome Medicine (2021)

Article

Clinical management of lung cancer patients during the outbreak of COVID-19 epidemic

The rapid growth of 2019 novel coronavirus (COVID-19) outbreak in Wuhan, China, at the early December 2019. COVID-19 spread all over the word just a few months. The outbreak of COVID-19 infection poses major t...

Li Wang, Man Jiang, Jialin Qu, Na Zhou, **aochun Zhang in Infectious Agents and Cancer (2020)

Article

Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer progression by cis-regulating the nearby gene MK5 and acting as a let-7f-1-3p sponge

Long noncoding RNAs (lncRNAs) are considered critical regulators in cancers; however, the clinical significance and mechanisms of MAPKAPK5-AS1 (hereinafter referred to as MK5-AS1) in colorectal cancer (CRC) re...

Ting Yang, Wei-Cong Chen, Pei-Cong Shi… in Journal of Experimental & Clinical Cancer … (2020)

Article

Antibody responses to SARS-CoV-2 in patients with COVID-19

We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG...

Quan-**n Long, Bai-Zhong Liu, Hai-Jun Deng, Gui-Cheng Wu, Kun Deng… in Nature Medicine (2020)

Article

USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer

USP13 has been reported to be involved in the tumorigenesis of human cancers, however, its functional role and regulatory mechanisms in bladder cancer (BC) remain unclear.

**aojun Man, Chiyuan Piao, Xuyong Lin… in Journal of Experimental & Clinical Cancer … (2019)

Article

Origin and evolution of the octoploid strawberry genome

Cultivated strawberry emerged from the hybridization of two wild octoploid species, both descendants from the merger of four diploid progenitor species into a single nucleus more than 1 million years ago. Here...

Patrick P. Edger, Thomas J. Poorten, Robert VanBuren… in Nature Genetics (2019)

Article

Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L.

Modern sugarcanes are polyploid interspecific hybrids, combining high sugar content from Saccharum officinarum with hardiness, disease resistance and ratooning of Saccharum spontaneum. Sequencing of a haploid S. ...

Jisen Zhang, **ngtan Zhang, Haibao Tang, Qing Zhang, **uting Hua… in Nature Genetics (2018)