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within Maik Kschischo Remove this filter Medicine & Public Health Remove this filter

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  1. Article

    Open Access

    Generation of realistic synthetic data using Multimodal Neural Ordinary Differential Equations

    Individual organizations, such as hospitals, pharmaceutical companies, and health insurance providers, are currently limited in their ability to collect data that are fully representative of a disease populati...

    Philipp Wendland, Colin Birkenbihl, Marc Gomez-Freixa… in npj Digital Medicine (2022)

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  2. Article

    Open Access

    The p53/p73 - p21CIP1 tumor suppressor axis guards against chromosomal instability by restraining CDK1 in human cancer cells

    Whole chromosome instability (W-CIN) is a hallmark of human cancer and contributes to the evolvement of aneuploidy. W-CIN can be induced by abnormally increased microtubule plus end assembly rates during mitos...

    Ann-Kathrin Schmidt, Karoline Pudelko, Jan-Eric Boekenkamp, Katharina Berger… in Oncogene (2021)

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  3. No Access

    Article

    Expression of regulators of mitotic fidelity are associated with intercellular heterogeneity and chromosomal instability in primary breast cancer

    Regulators of transition through mitosis such as SURVIVIN and Aurora kinase A (AURKA) have been previously implicated in the initiation of chromosomal instability (CIN), a driver of intratumour heterogeneity. ...

    Rebecca Roylance, David Endesfelder… in Breast Cancer Research and Treatment (2014)