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Article
Open AccessInhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A
The mycotoxin ochratoxin A (OTA) is a contaminant in food that causes nephrotoxicity and to a minor degree hepatotoxicity. Recently, we observed that OTA induces liver damage preferentially to the cytochrome P...
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Article
Open AccessColchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins
Colchicine is an anti-inflammatory drug with a narrow therapeutic index. Its binding to tubulin prevents microtubule polymerization; however, little is known about how depolymerization of microtubules interfer...
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Article
Open AccessHypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity
Hypoalbuminemia (HA) is frequently observed in systemic inflammatory diseases and in liver disease. However, the influence of HA on the pharmacokinetics and toxicity of compounds with high plasma albumin bindi...
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Article
Open AccessSubcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney
Local accumulation of xenobiotics in human and animal tissues may cause adverse effects. Large differences in their concentrations may exist between individual cell types, often due to the expression of specif...
