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  1. Article

    Open Access

    Arthritis augments breast cancer metastasis: role of mast cells and SCF/c-Kit signaling

    Breast cancer remains the second leading cause of cancer-related deaths for women in the United States. Metastasis is regulated not only by intrinsic genetic changes in malignant cells, but also by the microen...

    Lopamudra Das Roy, Jennifer M Curry, Mahnaz Sahraei… in Breast Cancer Research (2013)

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  2. Article

    Open Access

    Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches

    IL-17A is a pro-inflammatory cytokine that is normally associated with autoimmune arthritis and other pro-inflammatory conditions. Recently, IL-17A has emerged as a critical factor in enhancing breast cancer (...

    Lopamudra Das Roy, Mahnaz Sahraei, Jorge L Schettini, Helen E Gruber… in BMC Cancer (2014)

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  3. No Access

    Article

    DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation

    A negative regulator of the Wnt pathway secreted by tumor cells promotes immune evasion by suppressing lymphocyte cytotoxicity.

    Qian **ao, Jibo Wu, Wei-Jia Wang, Shiyang Chen, Yingxia Zheng… in Nature Medicine (2018)

  4. Article

    Open Access

    Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis

    Angiopoietin-like 4 (ANGPTL4) is known to regulate various cellular and systemic functions. However, its cell-specific role in endothelial cells (ECs) function and metabolic homeostasis remains to be elucidate...

    Balkrishna Chaube, Kathryn M. Citrin, Mahnaz Sahraei… in Nature Communications (2023)

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