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  1. No Access

    Article

    Preparation and preliminary evaluation of a tris-metronidazole-99mTc(CO)3 complex for targeting tumor hypoxia

    Conventional 99mTc-radiopharmaceuticals for the detection of tumor hypoxia generally possess a single nitroimidazole moiety. Herein, we report the synthesis and evaluation of a 99mTc-complex with three-nitroimida...

    Madhava B. Mallia, Anupam Mathur… in Journal of Radioanalytical and Nuclear Che… (2018)

  2. No Access

    Article

    Synthesis and evaluation of a novel 99mTcN(PNP)-complex with metronidazole isocyanide ligand as a marker for tumor hypoxia

    The [99mTcN(PNP)]2+ core offers a unique route for the preparation of asymmetric 99mTc-complexes. Though bidentate chelators such as dithiocarbamates are most commonly used ligands in this approach, present study...

    Kusum Vats, Madhava B. Mallia, Anupam Mathur… in Journal of Radioanalytical and Nuclear Che… (2016)

  3. No Access

    Article

    Neutral 99mTc(CO)3 complexes of “clicked” nitroimidazoles for the detection of tumor hypoxia

    In the present work, three neutral 99mTc(CO)3 complexes of nitroimidazole were synthesized and their potential to detect tumor hypoxia is evaluated in vivo. Triazole derivatives of 2-, 4- and 5-nitroimidazole wer...

    Mohini Bhadwal, Madhava B. Mallia… in Journal of Radioanalytical and Nuclear Che… (2016)