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Article
A sequence variation in the MOG gene is involved in multiple sclerosis susceptibility in Italy
Several studies suggest that the histocompatibility complex (HLA) class I region harbours genes modulating multiple sclerosis (MS) susceptibility independently from the effect of class II alleles. A candidate ...
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Article
Variations of the perforin gene in patients with multiple sclerosis
Perforin is involved in cell-mediated cytotoxicity and mutations of its gene (PRF1) cause familial hemophagocytic lymphohistiocytosis (FLH2). PRF1 sequencing in 190 patients with multiple sclerosis and 268 contro...
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Article
Open AccessHLA-class I markers and multiple sclerosis susceptibility in the Italian population
Previous studies reported an association with multiple sclerosis (MS) of distinct HLA-class I markers, namely HLA-A*02, HLA-Cw*05 and MOG-142L. In this work, we tested the association with MS of A*02 and Cw*05 in...