Vitamin D
Metabolism and Function
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26 Result(s)
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M. M. Grumbach
English
Medicine/Public Health, general
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Article
GROWTH AND ACROHEGALOID FEATURES IN A HYPOPHYSECTOMIZED (HY) MALE: THE ROLE OF PRANDIAL HYPERINSULINISM (HI)
Normal growth as well as acromegaloid features have been described in patients after HY for craniopharyngioma. This growth has been attributed to multiple factors including prolactin, ICF-I, insulin and anti-G...
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Article
MASSIVE VIRGINAL BREAST HYPERTROPHY AS A CAUSE OF RECURRENT HUMORAL HYPERCALCEMIA DUE TO PARATHYROID HORMONE-RELATED PROTEIN (PTHrP) SECRETION
Humoral hypercalcemia associated with certain neoplasms is caused by their secretion of a parathyroid-like 16-18 kd peptide, PTHrP. PTHrP also is expressed by keratinocytes, placenta, fetal parathyroids, and l...
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Article
N-METHYL-D-ASPARTATE (NMDA) STIMULATES LHRH RELEASE VIA THE NMDA RECEPTOR IN AN LHRH NEURONAL CELL LINE (GT1-1)
Previous studies demonstrated that an excitatory amino acid analog, NMDA, stimulates LHRH secretion in the ovine fetus, prepubertal primate and rat at the hypothalamic level. It is not known if this stimulator...
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Article
Treatment of Cushing's disease (C.D.) by transphenoidal microadenectomy (Tr.M.) in childhood and adolescence
The efficacy of Tr.M. in the treatment of C.D. in children and adolescents has not been assessed. We treated 8 patients (7-6/12-18-9/12 yrs old) with C.D. by Tr.M. (followup 8-72 months post-operatively). Grow...
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Article
Endocrinologic, biochemical and histologic characterization of an ectopic ACTH producing carcinoma in childhood
We studied a 10 yr old boy with Cushing's syndrome due to an ACTH secreting islet cell carcinoma of the pancreas. He had rapid weight gain, abdominal distention, proximal weakness but no hirsutism or striae. H...
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Article
Down-regulation of gonadotropin release by the ovine fetal pituitary gland by the superagonist D-Trp6pro9NET-LRF
D-Trp6Pro9NET-LRF (Trp6-LRF) a superagonist analogue of LRF has caused suppression of gonadotropin secretion when administered chronically in animals and in humans, but has not been studied in the fetus. In 3 chr...
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Article
451A TREATMENT OF CUSHINGS DISEASE (C.D.) BY TRANSPHENOIDAL MICROADENECTOMY (Tr.M.) IN CHILDHOOD AND ADOLESCENCE
The efficacy of Tr.M. in the treatment of C. D. in children and adolescents has not been assessed. We treated 7 patients (7-6/12 to 18-9/12 years old) with C.D. before epiphyseal fusion with Tr.M. (followup 2-...
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Article
383 CORTICOSTEROID BINDING GLOBULIN (CBG) IN FETAL AND NEWBORN SHEEP
To examine the ontogeny and regulation of CBG in the perinatal period, we determined plasma cortisol binding capacity using a charcoal absorption assay. CBG capacity increased progressively from 1.6 μg/dl at 7...
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Article
329 THE DEVELOPMENT OP CHOLINERGIC CONTROL OF GROWTH HORMONE (GH) SECRETION
As in man, acetylcholine stimulates GH release in adult sheep. The ontogeny of GH stimulation by cholinergic (muscarinic) agonists was studied in chronically catheterized fetal (term 147 days) and infant lambs...
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Article
284 ANTIBODIES TO LUTEINIZING HORMONE IN A PATIENT TREATED WITH GROWTH HORMONE
Many clinical grade preparations of hGH (human growth hormone) are contaminated with hLH and hFSH. However, no evidence of a clinical effect of such contamination has been described. We report the development ...
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Article
2 ESTROGEN TREATMENT OF PATIENTS WITH CONADAL DYSCENESIS
Commonly, estrogen therapy in patients with XO gonadal dysgenesis has been deferred until 15 yrs or later; it has been inferred that treatment with estrogen at an earlier age leads to rapid skeletal maturation...
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Article
315 ACTH-PRODUCING INTRACRANIAL TUMOR IN AN INFANT
ACTH-producing brain tumors in infancy are rare. An 8 month male was evaluated for a 4 month history of profound obesity, acne, moon-facies, hypertension, and hirsutism. An IVP and computerized tomographic (CT...
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Article
964 FETAL PROLACTIN (PRL) AND THE RESPIRATORY DISTRESS SYNDROME (RDS)
There is a temporal relationship between plasma PRL, cortisol (F) and pulmonary surfactant production in the fetus. PRL administered to fetal rabbits is reported to increase pulmonary surfactant content. To ex...
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339 THE ONTOGENY OF GONADOTROPINS AND SEX STEROIDS IN THE SHEEP FETUS
Using the chronically catheterized sheep fetus, the ontogeny of FSH, LH, testosterone (T), androstenedione (A), dehydroepian-drosterone (D), and D sulfate (DS) was studied in 84 fetuses from 70d to term (150d).
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Article
DEVELOPMENTAL PATTERN OF α SUBUNIT IN THE PREPUBERTAL AND PUBERTAL CHILD AND IN HYPERGONADOTROPIC HYPOGONADISM
Glycoprotein hormones share a common α subunit but each has a β subunit which confers biologic and immunologic specificity. α glycoprotein hormone subunit (α)is present in the adult pituitary in concentrations gr...
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Article
THE ONTOGENESIS OF SOMATOSTATIN IN THE FETAL RAT AND SHEEP PANCREAS
The localization of somatostatin (GIF) in pancreatic D cells and in the gastrointestinal tract led to the concept that SRIF may have a physiologic role at these sites as well as in the CNS. Its role in the fet...
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Book
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Article
STRUCTURE-FUNCTION RELATIONSHIPS IN THE HUMAN GROWTH HORMONE MOLECULE: IMPORTANCE OF MOLECULAR CONFORMATION IN RADIORECEPTOR ASSAY AND RADIOIMMUNOASSAY ACTIVITY
The conformational requirements for activity in hGH have been evaluated by comparing the activity of different derivatives and fragments of this hormone in two radioreceptor assays (RRA) and in several types o...
