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45 Accelerated Intravascular Coagulation in the Hemolytic Uremic Syndrome
Renal tissue was obtained by percutaneous biopsy in 11 patients with hemolytic uremic syndrome from 9 to 365 days after onset of disease; by autopsy in 5 after 6 to 58 days of illness. By light microscopy, the...
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60 Indications for and Consequences of Intrauterine Transfusions
We performed spectrophotometric analyses (technique of Liley) on 595 amniotic fluid specimens from 310 Rh-sensitized women; 1 or more specimens from 84 women had concentrations of pigment above levels which ar...
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Growth and Growth Hormone: I. changes in Serum Level of Growth Hormone Following Hypoglycemia in 134 children with Growth Rctardation
Extract: The change in levels of growth hormone in serum (SGH) following insulin-induced hypoglycemia was evaluated in 134 prepubertal children with growth retardation and 10 control subjects with normal growt...
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Effect of phenobarbital on bile salts in cholestasis
Phenobarbital (PB) reduces pruritis in children with cholestasis. Individual bile salts were determined before and during PB treatment in 3 children with intrahepatic cholestasis (2 with benign recurrent chole...
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THE RESPONSE TO LRF IN IDIOPATHIC PRECOCIOUS PUBERTY (IPP) AND CONGENITAL ADRENAL HYPERPLASIA (CAH)
We have previously shown that luteinizing hormone releasing factor (LRF) elicits a sharp increase in releasable LH at puberty. To evaluate premature neural activation of the hypothalamic gonadostat, 100 μg of ...
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PLASMA TSH AND PROLACTIN IN VARIOUS FORMS OF HYPOTHYROIDISM
Previous studies showed that thyrotropin releasing factor (TRF) stimulates thyrotropin (TSH) and prolactin (PRL) secretion. We compared plasma TSH and PRL in various forms of thyroid dysfunction. Plasma TSH an...
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STRUCTURE-FUNCTION RELATIONSHIPS IN THE HUMAN GROWTH HORMONE MOLECULE: IMPORTANCE OF MOLECULAR CONFORMATION IN RADIORECEPTOR ASSAY AND RADIOIMMUNOASSAY ACTIVITY
The conformational requirements for activity in hGH have been evaluated by comparing the activity of different derivatives and fragments of this hormone in two radioreceptor assays (RRA) and in several types o...
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THE ONTOGENESIS OF SOMATOSTATIN IN THE FETAL RAT AND SHEEP PANCREAS
The localization of somatostatin (GIF) in pancreatic D cells and in the gastrointestinal tract led to the concept that SRIF may have a physiologic role at these sites as well as in the CNS. Its role in the fet...
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DEVELOPMENTAL PATTERN OF α SUBUNIT IN THE PREPUBERTAL AND PUBERTAL CHILD AND IN HYPERGONADOTROPIC HYPOGONADISM
Glycoprotein hormones share a common α subunit but each has a β subunit which confers biologic and immunologic specificity. α glycoprotein hormone subunit (α)is present in the adult pituitary in concentrations gr...
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284 ANTIBODIES TO LUTEINIZING HORMONE IN A PATIENT TREATED WITH GROWTH HORMONE
Many clinical grade preparations of hGH (human growth hormone) are contaminated with hLH and hFSH. However, no evidence of a clinical effect of such contamination has been described. We report the development ...
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2 ESTROGEN TREATMENT OF PATIENTS WITH CONADAL DYSCENESIS
Commonly, estrogen therapy in patients with XO gonadal dysgenesis has been deferred until 15 yrs or later; it has been inferred that treatment with estrogen at an earlier age leads to rapid skeletal maturation...
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315 ACTH-PRODUCING INTRACRANIAL TUMOR IN AN INFANT
ACTH-producing brain tumors in infancy are rare. An 8 month male was evaluated for a 4 month history of profound obesity, acne, moon-facies, hypertension, and hirsutism. An IVP and computerized tomographic (CT...
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964 FETAL PROLACTIN (PRL) AND THE RESPIRATORY DISTRESS SYNDROME (RDS)
There is a temporal relationship between plasma PRL, cortisol (F) and pulmonary surfactant production in the fetus. PRL administered to fetal rabbits is reported to increase pulmonary surfactant content. To ex...
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339 THE ONTOGENY OF GONADOTROPINS AND SEX STEROIDS IN THE SHEEP FETUS
Using the chronically catheterized sheep fetus, the ontogeny of FSH, LH, testosterone (T), androstenedione (A), dehydroepian-drosterone (D), and D sulfate (DS) was studied in 84 fetuses from 70d to term (150d).
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