Skip to main content

7 Result(s)

within M Ryan Corces Remove this filter Life Sciences Remove this filter

and

  1. Article

    Open Access

    Systematic benchmarking of single-cell ATAC-sequencing protocols

    Single-cell assay for transposase-accessible chromatin by sequencing (scATAC-seq) has emerged as a powerful tool for dissecting regulatory landscapes and cellular heterogeneity. However, an exploration of syst...

    Florian V. De Rop, Gert Hulselmans, Chris Flerin, Paula Soler-Vila… in Nature Biotechnology (2024)

    Download PDF (9592 KB) View Article

  2. No Access

    Article

    Chromatin accessibility profiling by ATAC-seq

    The assay for transposase-accessible chromatin using sequencing (ATAC-seq) provides a simple and scalable way to detect the unique chromatin landscape associated with a cell type and how it may be altered by p...

    Fiorella C. Grandi, Hailey Modi, Lucas Kampman, M. Ryan Corces in Nature Protocols (2022)

  3. No Access

    Article

    LKB1 inactivation modulates chromatin accessibility to drive metastatic progression

    Metastasis is the leading cause of cancer-related deaths and enables cancer cells to compromise organ function by expanding in secondary sites. Since primary tumours and metastases often share the same constel...

    Sarah E. Pierce, Jeffrey M. Granja, M. Ryan Corces… in Nature Cell Biology (2021)

  4. No Access

    Article

    Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia

    Identifying the causes of human diseases requires deconvolution of abnormal molecular phenotypes spanning DNA accessibility, gene expression and protein abundance1–3. We present a single-cell framework that integ...

    Jeffrey M. Granja, Sandy Klemm, Lisa M. McGinnis, Arwa S. Kathiria… in Nature Biotechnology (2019)

  5. No Access

    Article

    Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

    Understanding complex tissues requires single-cell deconstruction of gene regulation with precision and scale. Here, we assess the performance of a massively parallel droplet-based method for map** transposa...

    Ansuman T. Satpathy, Jeffrey M. Granja, Kathryn E. Yost, Yanyan Qi… in Nature Biotechnology (2019)

  6. No Access

    Article

    HiChIRP reveals RNA-associated chromosome conformation

    Modular domains of long non-coding RNAs can serve as scaffolds to bring distant regions of the linear genome into spatial proximity. Here, we present HiChIRP, a method leveraging bio-orthogonal chemistry and o...

    Maxwell R. Mumbach, Jeffrey M. Granja, Ryan A. Flynn, Caitlin M. Roake… in Nature Methods (2019)

  7. No Access

    Article

    An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

    The Omni-ATAC protocol improves the signal-to-background ratio in chromatin accessibility profiles and is suitable for a range of cell lines and primary cell types, as well as frozen tissue.

    M Ryan Corces, Alexandro E Trevino, Emily G Hamilton, Peyton G Greenside… in Nature Methods (2017)