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  1. No Access

    Article

    Promoter CpG hypermethylation and downregulation of XAF1 expression in human urogenital malignancies: implication for attenuated p53 response to apoptotic stresses

    XIAP-associated factor 1 (XAF1) is a new candidate tumor suppressor, which has been known to exert proapoptotic effects by interfering with the caspase-inhibiting activity of XIAP. To explore the XAF1's candid...

    M-G Lee, J-S Huh, S-K Chung, J-H Lee, D-S Byun, B-K Ryu, M-J Kang, K-S Chae in Oncogene (2006)

  2. No Access

    Article

    Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions

    Transforming growth factor (TGF)-β1 has biphasic functions in prostate tumorigenesis, having a growth-inhibitory effect in the early stages, but in the late stages promoting tumor angiogenesis and metastasis. ...

    K S Chae, M J Kang, J H Lee, B K Ryu, M G Lee, N G Her, T K Ha, J Han, Y K Kim in Oncogene (2011)

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    Article

    p21-Activated kinase 4 promotes prostate cancer progression through CREB

    Prostate cancer is initially androgen-dependent but, over time, usually develops hormone- and chemo-resistance. The present study investigated a role for p21-activated kinase 4 (PAK4) in prostate cancer progre...

    M-H Park, H-S Lee, C-S Lee, S T You, D-J Kim, B-H Park, M J Kang, W D Heo in Oncogene (2013)

  4. Article

    ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21WAF1

    ZNF313 encoding a zinc-binding protein is located at chromosome 20q13.13, which exhibits a frequent genomic amplification in multiple human cancers. However, the biological function of ZNF313 remains largely u...

    J Han, Y-L Kim, K-W Lee, N-G Her, T-K Ha, S Yoon, S-I Jeong in Cell Death & Differentiation (2013)

  5. Article

    Open Access

    Crucial role of calbindin-D28k in the pathogenesis of Alzheimer’s disease mouse model

    Calbindin-D28k (CB), one of the major calcium-binding and buffering proteins, has a critical role in preventing a neuronal death as well as maintaining calcium homeostasis. Although marked reductions of CB expres...

    S-Y Kook, H Jeong, M J Kang, R Park, H J Shin, S-H Han in Cell Death & Differentiation (2014)