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Article

Heterogeneity of O⁶-alkylguanine DNA-alkyltransferase expression in human breast tumours

An important determinant of cellular resistance to chemotherapeutic O⁶-alkylating agents, which comprise methylating and chloroethylating agents, is the ability of cells to repair alkylation damage at the O⁶-posi...

M J Clemons, M C Bibby, H El Teraifi, G Forster, J Kelly… in British Journal of Cancer (2002)