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  1. No Access

    Article

    A Minimal PBPK Model for Plasma and Cerebrospinal Fluid Pharmacokinetics of Trastuzumab after Intracerebroventricular Administration in Patients with HER2-Positive Brain Metastatic Localizations

    Dosing regimens of trastuzumab administered by intracerebroventricular (icv) route to patients with HER2-positive brain localizations remain empirical. The objectives of this study were to describe pharmacokin...

    Alicja Puszkiel, Guilhem Bousquet, Françoise Stanke-Labesque… in Pharmaceutical Research (2023)

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    Article

    The neurobehavioral effects of the designer drug naphyrone – an experimental investigation with pharmacokinetics and concentration/effect relationship in mice

    The recreational use of naphyrone, a potent synthetic cathinone with a pyrovalerone structure, has raised questions about possible deleterious neurobehavioral consequences.

    Bruno Mégarbane, Camille Gamblin, Olivier Roussel… in Psychopharmacology (2020)

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    Article

    Is the 3,4-methylendioxypyrovalerone/mephedrone combination responsible for enhanced stimulant effects? A rat study with investigation of the effect/concentration relationships

    The use of synthetic cathinones as recreational drugs frequently sold in combination has been increasing exponentially. However, the consequences of combining cathinones on the resulting stimulant effects and ...

    Nadia Benturquia, Lucie Chevillard, Christophe Poiré, Olivier Roussel… in Psychopharmacology (2019)