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Article
Exploring the causal association between serum metabolites and erectile dysfunction: a bidirectional Mendelian randomisation study
Erectile dysfunction is a common sexual disorder in men. Some studies have found a strong association between some serum metabolites and erectile dysfunction. To investigate this association further, we used b...
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Article
Salinity affects C/N ratio through differential responses of carbon and nitrogen metabolism in mangrove Avicennia marina leaves revealed by combined analysis of transcriptome and metabolome
Salt is a critical environmental factor that profoundly impacts plant growth and development. However, the investigation into how plants regulate carbon and nitrogen metabolism in response to different levels ...
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Article
Molecular Chain Flexibility and Dielectric Loss at High-Frequency: Impact of Ester Bond Arrangement in Poly(ester imide)s
The evolution of high-frequency communication has accentuated the significance of controlling dielectric properties in polymer media. Traditionally, it has been theorized that rigid molecular chains lead to lo...
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Article
Association between Serum Ferritin Levels and Metabolic-associated Fatty Liver Disease in Adults: a Cross-sectional Study Based on the NHANES
Ferritin, initially acting as an iron-storage protein, was found to be associated with metabolic diseases. Our study was designed to investigate the association between serum ferritin and metabolic-associated ...
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Article
Fault and lithology interpretation for the northern coastal zone of Taizhou based on aeromagnetic data
The northern coastal zone of Taizhou spans three tectonic units: the North China Block, Lower Yangtze Block, and Cathaysian Block. The regional geological structure is complex, magmatic activity is strong, and...
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Article
A potent new-scaffold androgen receptor antagonist discovered on the basis of a MIEC-SVM model
Prostate cancer (PCa) is the second most prevalent malignancy among men worldwide. The aberrant activation of androgen receptor (AR) signaling has been recognized as a crucial oncogenic driver for PCa and AR a...
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Article
Active tectonic deformation and its seismic–geological significance of boundary faults of the Daxing Uplift and Langgu–Dachang Depression, Bei**g Plain, China
Boundary faults of the Daxing Uplift and Langgu–Dachang Depression are located in the southeastern region of the Bei**g Plain and directly control the sedimentation, tectonic evolution, and strong seismic act...
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Article
Oxidation resistant low-alloyed Ti alloys with good ductility
Oxidation resistance enhancement of pure Ti often comes at the cost of reduced ductility, which is frequently the problem through alloying with sole Al, Si, W, Mo and B. To overcome the short coming of single ...
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Article
Effects of calcitonin on lumbar spinal stenosis
Systematic review and meta-analysis.
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Article
Isolation of Rhizobacteria from Crocus Sativus L. Rhizosphere and Their Effects on Host-Growth Promotion
Corms serve as the primary mode of reproduction for saffron, which growth state determines the yield and quality of saffron under field cultivation conditions. In this study, fourteen rhizobacteria were isolat...
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Article
Dielectric Constant Calculation of Poly(vinylidene fluoride) Based on Finite Field and Density Functional Theory
In this study, we proposed a novel method that integrates density functional theory (DFT) with the finite field method to accurately estimate the polarizability and dielectric constant of polymers. Our approac...
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Article
Open AccessThe effect of topological design on the degradation behavior of additively manufactured porous zinc alloy
The advent of additively manufactured biodegradable porous metals presents a transformative opportunity to meet the criteria of ideal bone substitutes. Precisely tailoring their degradation behavior constitute...
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Article
Advances in biotin biosynthesis and biotechnological production in microorganisms
Biotin, also known as vitamin H or B7, acts as a crucial cofactor in the central metabolism processes of fatty acids, amino acids, and carbohydrates. Biotin has important applications in food additives, biomedici...
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Article
Open AccessSociodemographic, clinical and treatment characteristics of current rapid-cycling bipolar disorder: a multicenter Chinese study
Rapid cycling bipolar disorder (RCBD), characterized by four or more episodes per year, is a complex subtype of bipolar disorder (BD) with poorly understood characteristics.
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Article
Open AccessIdentification of immune-associated biomarker for predicting lung adenocarcinoma: bioinformatics analysis and experiment verification of PTK6
Abnormal expression of protein tyrosine kinase 6 (PTK6) has been proven to be involved in the development of gynecological tumors. However, its immune-related carcinogenic mechanism in other tumors remains unc...
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Article
Open AccessXELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...
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Article
Open AccessSerum sex hormones correlate with pathological features of papillary thyroid cancer
Sex hormones are thought to be responsible for the unique gender differences in papillary thyroid cancer(PTC). Most previous studies on these have focused on the expression of estrogen receptors, or have been ...
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Article
Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial
Epigenetic modifications of chromatin, including histone acetylation, and tumor angiogenesis play pivotal roles in creating an immunosuppressive tumor microenvironment. In the randomized phase 2 CAPability-01 ...
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Article
The influence of in situ purification system on pathogen in the river fed by the drainage of sewage plant
An in situ integrated system, consisting of ecological floating islands (EFI), ecological riverbeds (ER), and ecological filter dams (EFD), was built in a ditch only receiving the effluent of sewage plant; the...
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Article
Ratiometric electrochemiluminescence sensing and intracellular imaging of ClO− via resonance energy transfer
Electrochemiluminescence resonance energy transfer (ECL-RET) is a versatile signal transduction strategy widely used in the fabrication of chem/biosensors. However, this technique has not yet been applied in v...
