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  1. Article

    Open Access

    Nicotinamide Riboside, an NAD + Precursor, Protects Against Cardiac Mitochondrial Dysfunction in Fetal Guinea Pigs Exposed to Gestational Hypoxia

    Gestational hypoxia inhibits mitochondrial function in the fetal heart and placenta contributing to fetal growth restriction and organ dysfunction. NAD + deficiency may contribute to a metabolic deficit by inh...

    Loren P. Thompson, Hong Song, Jamie Hartnett in Reproductive Sciences (2024)

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  2. Article

    Open Access

    Effects of Gestational Hypoxia on PGC1α and Mitochondrial Acetylation in Fetal Guinea Pig Hearts

    Chronic intrauterine hypoxia is a significant pregnancy complication impacting fetal heart growth, metabolism, and mitochondrial function, contributing to cardiovascular programming of the offspring. PGC1α (pe...

    Hong Song, Loren P. Thompson in Reproductive Sciences (2023)

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  3. No Access

    Article

    Sex-Selective Increase of IGF-2 Expression in the Hypoxic Guinea Pig Placenta of Growth-Restricted Fetuses

    Chronic hypoxia can cause fetal growth restriction (FGR) through placental dysfunction. Insulin-like growth factors (IGFs), such as IGF-2, play a major role in preservation of placental growth and function. We...

    Emad A. Elsamadicy, Loren P. Thompson in Reproductive Sciences (2022)

  4. No Access

    Article

    Chronic Hypoxia Inhibits Respiratory Complex IV Activity and Disrupts Mitochondrial Dynamics in the Fetal Guinea Pig Forebrain

    Mitochondrial dysfunction is an underlying cause of childhood neurological disease secondary to the crucial role of mitochondria in proper neurodevelopment. We hypothesized that chronic intrauterine hypoxia (H...

    Tabitha M. Quebedeaux, Hong Song, Jamiu Giwa-Otusajo… in Reproductive Sciences (2022)

  5. No Access

    Article

    Chronic Hypoxia Impairs Cytochrome Oxidase Activity Via Oxidative Stress in Selected Fetal Guinea Pig Organs

    We hypothesized that chronic hypoxia disrupts mitochondrial function via oxidative stress in fetal organs. Pregnant guinea pig sows were exposed to either normoxia or hypoxia (10.5% O2, 14 days) in the presence o...

    Yazan M. Al-Hasan, LaShauna C. Evans, Gerard A. Pinkas… in Reproductive Sciences (2013)