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within Longci Sun Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. Article

    Open Access

    FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer

    Colonocyte metabolism shapes the microbiome. Metabolites are the main mediators of information exchange between intestine and microbial communities. Arachidonic acid (AA) is an essential polyunsaturated fatty ...

    Chunjie Xu, Lei Gu, Lipeng Hu, Chunhui Jiang, Qing Li, Longci Sun… in Nature Communications (2023)

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  2. Article

    Open Access

    Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer

    PI3Ks consist of p110 catalytic subunits and p85 regulatory subunits. PIK3CA, encoding p110α, is frequently mutated in human cancers. Most PIK3CA mutations are clustered in the helical domain or the kinase domain...

    Yujun Hao, Baoyu He, Li** Wu, Yamu Li, Chao Wang, Ting Wang… in Nature Communications (2022)

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