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    Article

    Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1

    Defects in the prelamin A processing enzyme caused by loss-of-function mutations in the ZMPSTE24 gene are responsible for a spectrum of progeroid disorders characterized by the accumulation of farnesylated prelam...

    Yuanxin Yang, Jian Zhang, Mingming lv, Na Cui, Bing Shan, Qi Sun… in Nature Cell Biology (2024)