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Open AccessArchitecture design and advanced manufacturing of heart-on-a-chip: scaffolds, stimulation and sensors
Heart-on-a-chip (HoC) has emerged as a highly efficient, cost-effective device for the development of engineered cardiac tissue, facilitating high-throughput testing in drug development and clinical treatment....
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Article
Open AccessDigital light processing printed hydrogel scaffolds with adjustable modulus
Hydrogels are extensively explored as biomaterials for tissue scaffolds, and their controlled fabrication has been the subject of wide investigation. However, the tedious mechanical property adjusting process ...
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Article
Open AccessCorrection: Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/ GPX4 expression
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Open AccessRituximab potentially improves clinical outcomes of CAR-T therapy for r/r B-ALL via sensitizing leukemia cells to CAR-T-mediated cytotoxicity and reducing CAR-T exhaustion
Despite chimeric antigen receptor (CAR) T-cell therapy has achieved great advances in recent year, approximately 50% of relapsed/refractory B cell acute lymphoblastic leukemia (r/r B-ALL) patients treated with...
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Open AccessTargeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression
Ferroptosis is a newly identified iron-dependent form of death that is becoming increasingly recognized as a promising avenue for cancer therapy. N6-methyladenosine (m6A) is the most abundant reversible methylati...
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Article
Open AccessStructurally diverse macrocycle co-crystals for solid-state luminescence modulation
Organic co-crystals offer an opportunity to fabricate organic functional materials. Traditional co-crystals are generally packed following the segregated or mixed stacking mode, leading to the lack of structur...
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Article
Open AccessJMJD3 regulate H3K27me3 modification via interacting directly with TET1 to affect spermatogonia self-renewal and proliferation
In epigenetic modification, histone modification and DNA methylation coordinate the regulation of spermatogonium. Not only can methylcytosine dioxygenase 1 (TET1) function as a DNA demethylase, converting 5-me...
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Article
Open AccessThe association of lymphocyte with hypothyroidism in obstructive sleep apnea
Obstructive sleep apnea (OSA) is a common sleep-breathing disorder. Numerous investigations have found a strong inherent relationship between OSA and hypothyroidism. Studies suggest that lymphocytes may be inv...
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Article
Open AccessGeneration of a new therapeutic d-peptide that induces the differentiation of acute myeloid leukemia cells through A TLR-2 signaling pathway
Acute myeloid leukemia (AML) is caused by clonal disorders of hematopoietic stem cells. Differentiation therapy is emerging as an important treatment modality for leukemia, given its less toxicity and wider ap...
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Article
Open AccessClinical implications of myeloid malignancy‑related somatic mutations in aplastic anemia
Aplastic anemia (AA) is a potentially fatal bone marrow failure syndrome characterized by a paucity of hematopoietic stem cells and progenitor cells with varying degrees of cytopenia and fatty infiltration of ...
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Article
Open AccessPredicting response to CCRT for esophageal squamous carcinoma by a radiomics-clinical SHAP model
Radical concurrent chemoradiotherapy (CCRT) is frequently used as the first-line treatment for patients with locally advanced esophageal cancer. Unfortunately, some patients respond poorly. To predict response...
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Article
Open AccessHK3 stimulates immune cell infiltration to promote glioma deterioration
Glioma is the most common and lethal type of brain tumor, and it is characterized by unfavorable prognosis and high recurrence rates. The reprogramming of energy metabolism and an immunosuppressive tumor micro...
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Article
Open AccessHDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation
Lysine succinylation is one of the major post-translational modifications occurring on histones and is believed to have significant roles in regulating chromatin structure and function. Currently, histone desu...
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Open AccessAsparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response
Robust and effective T cell immune surveillance and cancer immunotherapy require proper allocation of metabolic resources to sustain energetically costly processes, including growth and cytokine production. He...
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Open AccessDecitabine in combination with fludarabine and cyclophosphamide as a lymphodepletion regimen followed by CD19/CD22 bispecific targeted CAR T-cell therapy significantly improves survival in relapsed/refractory B-ALL patients
Relapse is a major limitation of chimeric antigen receptor (CAR) T-cell therapy. Here, we speculated that decitabine (DAC) in combination with fludarabine and cyclophosphamide (FC) as a lymphodepletion regimen...
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Open AccessSuccessful mechanical thrombectomy in acute bilateral M1 middle cerebral artery occlusion: a case report and literature review
Acute bilateral occlusion of the middle cerebral artery (MCA) is a very rare condition, and most cases are accompanied by a poor prognosis. However, mechanical thrombectomy (MT) for bilateral MCA is challengin...
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Open AccessThe UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation
Impaired protein N-glycosylation leads to the endoplasmic reticulum (ER) stress, which triggers adaptive survival or maladaptive apoptosis in renal tubules in diabetic kidney disease (DKD). Therapeutic strateg...
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Open AccessAssociations of metal profiles in blood with thyroiditis: a cross-sectional study
Autoimmune thyroiditis (AIT) is increasingly common, and serological markers include thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb). To determine if selected metals influence thyroiditis...
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Article
Open AccessGAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation
γ-Aminobutyrate (GAB), the biochemical form of (GABA) γ-aminobutyric acid, participates in sha** physiological processes, including the immune response. How GAB metabolism is controlled to mediate such funct...
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Open AccessA novel antimicrobial peptide found in Pelophylax nigromaculatus
Many active peptides have been found in frog skin secretions. In this paper, our research focused on Pelophylax nigromaculatus and found a broad-spectrum antimicrobial peptide Nigrocin-PN based on the molecular c...
