9 Result(s)

Article

Smad3-related miRNAs regulated oncogenic TRIB2 promoter activity to effectively suppress lung adenocarcinoma growth

MicroRNAs (miRNAs) and Smad3, as key transcription factors in transforming growth factor-β1 (TGF-β1) signaling, help regulate various physiological and pathological processes. We investigated the roles of Smad3-r...

Yan-**a Zhang, Yun-Fei Yan, Yue-Mei Liu, You-Jie Li, Han-Han Zhang… in Cell Death & Disease (2016)

Article

Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity

Deltarasin is a recently identified small molecule that can inhibit KRAS–PDEδ interactions by binding to a hydrophobic pocket on PDEδ, resulting in the impairment of cell growth, KRAS activity, and RAS/RAF sig...

Elaine Lai Han Leung, Lian **ang Luo, Zhong Qiu Liu… in Cell Death & Disease (2018)

Article

Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N‑acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress

Pharmacological inhibition of reactive oxygen species (ROS) is a potential strategy to prevent diabetes-induced cardiac dysfunction. This study was designed to investigate precise effects of antioxidant N‑acetylc...

Yang He, Lingyun Zhou, Zhiqiang Fan, Shikun Liu, Wei** Fang in Cell Death & Disease (2018)

Article

Deep RNA sequencing reveals the dynamic regulation of miRNA, lncRNAs, and mRNAs in osteosarcoma tumorigenesis and pulmonary metastasis

Osteosarcoma (OS) is the most common pediatric malignant bone tumor, and occurrence of pulmonary metastasis generally causes a rapid and fatal outcome. Here we aimed to provide clues for exploring the mechanis...

Lin **e, Zhihong Yao, Ya Zhang, Dongqi Li, Fengdi Hu, Yedan Liao… in Cell Death & Disease (2018)

Article

Polybrene induces neural degeneration by bidirectional Ca²⁺ influx-dependent mitochondrial and ER–mitochondrial dynamics

Hexadimethrine bromide (Polybrene) was once used clinically as a heparin neutralizer and has recently found use as a promoter in virus-mediated gene therapy trials and gene transfer in research. However, the p...

Feixiang Bao, Hongyan Shi, Mi Gao, Liang Yang, Lingyan Zhou… in Cell Death & Disease (2018)

Article

APN-mediated phosphorylation of BCKDK promotes hepatocellular carcinoma metastasis and proliferation via the ERK signaling pathway

Hepatocellular carcinoma (HCC) is one of the most prevalent human malignancies worldwide and has high morbidity and mortality. Elucidating the molecular mechanisms underlying HCC recurrence and metastasis is c...

Mengying Zhai, Zixia Yang, Chenrui Zhang, **** Li, **g Jia… in Cell Death & Disease (2020)

Article

STAT6 contributes to renal fibrosis by modulating PPARα-mediated tubular fatty acid oxidation

Lipid metabolism, especially fatty acid oxidation (FAO) dysfunction, is a major driver of renal fibrosis; however, the detailed regulatory mechanisms involved remain unclear. In this study, we showed that ther...

Jianzhong Li, You**g Yang, Qianmin Li, Shuhui Wei, Yujia Zhou… in Cell Death & Disease (2022)

Article

Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE

Yinghui Wei, Chunlong Xu, Hu Feng, Kui Xu, Zhifang Li, **g Hu, Ling Zhou… in Cell Discovery (2022)

Article

Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity

Endometriosis (EMs) occurs in approximately 50% of women with infertility. The main causes of EMs-related infertility are follicle dysplasia and reduced oocyte quality. Iron overload occurs in ovarian follicul...

Zhexin Ni, Yangshuo Li, Di Song, Jie Ding, Shanshan Mei, Shuai Sun… in Cell Death & Disease (2022)