18 Result(s)

Article

miR-150-5p in neutrophil-derived extracellular vesicles associated with sepsis-induced cardiomyopathy in septic patients

Early diagnosis and potential therapeutic targets of sepsis-induced cardiomyopathy (SIC) remain challenges clinically. Circulating extracellular vesicles from immune cells carrying crucial injurious mediators,...

Rongzong Ye, Qiuyun Lin, Wenkai **ao, Lixia Mao, Pengfei Zhang… in Cell Death Discovery (2023)

Article

The role of the TGF-β/LIF signaling pathway mediated by SMADs during the cyst formation of Echinococcus in young children

The present study aims to explore the correlation of the transforming growth factor β (TGF-β), drosophila mothers against decapentaplegic protein gene (SMAD) 2/3/4, and leukemia inhibitory factors (LIF) with t...

Shuang-li Qin, Yun Guo, Shui-Xue Li, Ling Zhou… in BMC Molecular and Cell Biology (2022)

Article

Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity

Endometriosis (EMs) occurs in approximately 50% of women with infertility. The main causes of EMs-related infertility are follicle dysplasia and reduced oocyte quality. Iron overload occurs in ovarian follicul...

Zhexin Ni, Yangshuo Li, Di Song, Jie Ding, Shanshan Mei, Shuai Sun… in Cell Death & Disease (2022)

Article

GRP78 blockade overcomes intrinsic resistance to UBA1 inhibitor TAK-243 in glioblastoma

Glioblastoma multiforme (GBM) is the most aggressive malignant primary brain tumor of the central nervous system. Despite continuous progression in treatment options for GBM like surgery, radiotherapy, and che...

Xu Zhang, Runqiu Wu, Cong Tian, Wanzhou Wang, Lingni Zhou… in Cell Death Discovery (2022)

Article

Attenuated succinate accumulation relieves neuronal injury induced by hypoxia in neonatal mice

Hypoxia causes neonatal neuronal damage. However, the underlying mechanism remains unclear. This study aimed to explore the changes in succinate levels and identify the mechanisms underlying their contribution...

Mengdi Zhang, Yao Cheng, Yujie Zhai, Yaru Cui, Wenshen Zhang… in Cell Death Discovery (2022)

Article

Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE

Yinghui Wei, Chunlong Xu, Hu Feng, Kui Xu, Zhifang Li, **g Hu, Ling Zhou… in Cell Discovery (2022)

Article

STAT6 contributes to renal fibrosis by modulating PPARα-mediated tubular fatty acid oxidation

Lipid metabolism, especially fatty acid oxidation (FAO) dysfunction, is a major driver of renal fibrosis; however, the detailed regulatory mechanisms involved remain unclear. In this study, we showed that ther...

Jianzhong Li, You**g Yang, Qianmin Li, Shuhui Wei, Yujia Zhou… in Cell Death & Disease (2022)

Article

Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma

Glioblastoma (GBM) is an incurable and highly heterogeneous brain tumor, originating from human neural stem/progenitor cells (hNSCs/hNPCs) years ahead of diagnosis. Despite extensive efforts to characterize hN...

**aofei Wang, Ran Zhou, Yanzhen **ong, Lingling Zhou, **ang Yan… in Cell Research (2021)

Article

APN-mediated phosphorylation of BCKDK promotes hepatocellular carcinoma metastasis and proliferation via the ERK signaling pathway

Hepatocellular carcinoma (HCC) is one of the most prevalent human malignancies worldwide and has high morbidity and mortality. Elucidating the molecular mechanisms underlying HCC recurrence and metastasis is c...

Mengying Zhai, Zixia Yang, Chenrui Zhang, **** Li, **g Jia… in Cell Death & Disease (2020)

Article

Polybrene induces neural degeneration by bidirectional Ca²⁺ influx-dependent mitochondrial and ER–mitochondrial dynamics

Hexadimethrine bromide (Polybrene) was once used clinically as a heparin neutralizer and has recently found use as a promoter in virus-mediated gene therapy trials and gene transfer in research. However, the p...

Feixiang Bao, Hongyan Shi, Mi Gao, Liang Yang, Lingyan Zhou… in Cell Death & Disease (2018)

Article

Deep RNA sequencing reveals the dynamic regulation of miRNA, lncRNAs, and mRNAs in osteosarcoma tumorigenesis and pulmonary metastasis

Osteosarcoma (OS) is the most common pediatric malignant bone tumor, and occurrence of pulmonary metastasis generally causes a rapid and fatal outcome. Here we aimed to provide clues for exploring the mechanis...

Lin **e, Zhihong Yao, Ya Zhang, Dongqi Li, Fengdi Hu, Yedan Liao… in Cell Death & Disease (2018)

Article

Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N‑acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress

Pharmacological inhibition of reactive oxygen species (ROS) is a potential strategy to prevent diabetes-induced cardiac dysfunction. This study was designed to investigate precise effects of antioxidant N‑acetylc...

Yang He, Lingyun Zhou, Zhiqiang Fan, Shikun Liu, Wei** Fang in Cell Death & Disease (2018)

Article

Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity

Deltarasin is a recently identified small molecule that can inhibit KRAS–PDEδ interactions by binding to a hydrophobic pocket on PDEδ, resulting in the impairment of cell growth, KRAS activity, and RAS/RAF sig...

Elaine Lai Han Leung, Lian **ang Luo, Zhong Qiu Liu… in Cell Death & Disease (2018)

Article

Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells

DNA double-strand breaks (DSBs) are traditionally associated with cancer through their abilities to cause chromosomal instabilities or gene mutations. Here we report a new class of self-inflicted DNA DSBs that...

**njian Liu, Fang Li, Qian Huang, Zhengxiang Zhang, Ling Zhou, Yu Deng… in Cell Research (2017)

Article

Smad3-related miRNAs regulated oncogenic TRIB2 promoter activity to effectively suppress lung adenocarcinoma growth

MicroRNAs (miRNAs) and Smad3, as key transcription factors in transforming growth factor-β1 (TGF-β1) signaling, help regulate various physiological and pathological processes. We investigated the roles of Smad3-r...

Yan-**a Zhang, Yun-Fei Yan, Yue-Mei Liu, You-Jie Li, Han-Han Zhang… in Cell Death & Disease (2016)

Article

Photoperiod- and thermo-sensitive genic male sterility in rice are caused by a point mutation in a novel noncoding RNA that produces a small RNA

Photoperiod- and thermo-sensitive genic male sterility (PGMS and TGMS) are the core components for hybrid breeding in crops. Hybrid rice based on the two-line system using PGMS and TGMS lines has been successf...

Hai Zhou, Qinjian Liu, **g Li, Dagang Jiang, Lingyan Zhou, ** Wu… in Cell Research (2012)

Article

Isolation of mouse mesenchymal stem cells with normal ploidy from bone marrows by reducing oxidative stress in combination with extracellular matrix

Isolation of mouse MSCs (mMSCs) with normal ploidy from bone marrow remains challenging. mMSCs isolated under 20% O₂ are frequently contaminated by overgrown hematopoietic cells, and could also be especially vuln...

Guokuan Fan, Lai Wen, Minshu Li, Chao Li, Ben** Luo, Fang Wang… in BMC Cell Biology (2011)

Article

Telomere reprogramming early in development and cloning

Lin Liu, Maja Okuka, Chao Li, Lingjun Zhou, Chao Wu, David L Keefe… in Cell Research (2008)