58 Result(s)

Article

Emerging trends in the coexistence of primary lung Cancer and hematologic malignancy: a comprehensive analysis of clinicopathological features and genetic abnormalities

The incidence of multiple primary cancers (MPC), especially involving primary lung cancer (PLC) and primary hematologic malignancies (PHM), is rising. This study aims to analyze clinicopathological features, g...

Mengchen Lyu, Lifeng Luo, Ling Zhou, **angran Feng, ** Yang… in Cancer Cell International (2024)

Article

Comprehensive bioinformatics analysis of the solute carrier family and preliminary exploration of SLC25A29 in lung adenocarcinoma

According to the latest epidemiological investigation, lung adenocarcinoma (LUAD) is one of the most fatal cancer among both men and women. Despite continuous advancements in treatment approaches in recent yea...

Pengdou Zheng, Zhenyu Mao, Miao Luo, Ling Zhou, Lingling Wang… in Cancer Cell International (2023)

Article

WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein

Large tumor suppressor kinase 1 (LATS1), one of the predominant components of the Hippo pathway, has been characterized as a key player controlling the proliferation and invasion of cancer cells, including gas...

Jian** Zou, Ling Zhou, Yi Le, Zhi Fang, Min Zhong… in Cell Communication and Signaling (2023)

Article

miR-150-5p in neutrophil-derived extracellular vesicles associated with sepsis-induced cardiomyopathy in septic patients

Early diagnosis and potential therapeutic targets of sepsis-induced cardiomyopathy (SIC) remain challenges clinically. Circulating extracellular vesicles from immune cells carrying crucial injurious mediators,...

Rongzong Ye, Qiuyun Lin, Wenkai **ao, Lixia Mao, Pengfei Zhang… in Cell Death Discovery (2023)

Article

The role of the TGF-β/LIF signaling pathway mediated by SMADs during the cyst formation of Echinococcus in young children

The present study aims to explore the correlation of the transforming growth factor β (TGF-β), drosophila mothers against decapentaplegic protein gene (SMAD) 2/3/4, and leukemia inhibitory factors (LIF) with t...

Shuang-li Qin, Yun Guo, Shui-Xue Li, Ling Zhou… in BMC Molecular and Cell Biology (2022)

Article

The Role of Mitochondrial Quality Control in Cognitive Dysfunction in Diabetes

Type 2 diabetes (T2DM) is a well known risk factor for Alzheimer’s disease. Mitochondria are the center of intracellular energy metabolism and the main source of reactive oxygen species. Mitochondrial dysfunct...

Jian-Sheng Luo, Jia-Qi Ning, Zhuo-Ya Chen, Wen-**g Li… in Neurochemical Research (2022)

Article

Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity

Endometriosis (EMs) occurs in approximately 50% of women with infertility. The main causes of EMs-related infertility are follicle dysplasia and reduced oocyte quality. Iron overload occurs in ovarian follicul...

Zhexin Ni, Yangshuo Li, Di Song, Jie Ding, Shanshan Mei, Shuai Sun… in Cell Death & Disease (2022)

Article

Mesh-like electrospun membrane loaded with atorvastatin facilitates cutaneous wound healing by promoting the paracrine function of mesenchymal stem cells

Functional electrospun membranes are promising dressings for promoting wound healing. However, their microstructure and drug loading capacity need further improvements. It is the first time to design a novel m...

Jieyu **ang, Ling Zhou, Yuanlong **e, Yufan Zhu… in Stem Cell Research & Therapy (2022)

Article

GRP78 blockade overcomes intrinsic resistance to UBA1 inhibitor TAK-243 in glioblastoma

Glioblastoma multiforme (GBM) is the most aggressive malignant primary brain tumor of the central nervous system. Despite continuous progression in treatment options for GBM like surgery, radiotherapy, and che...

Xu Zhang, Runqiu Wu, Cong Tian, Wanzhou Wang, Lingni Zhou… in Cell Death Discovery (2022)

Article

Attenuated succinate accumulation relieves neuronal injury induced by hypoxia in neonatal mice

Hypoxia causes neonatal neuronal damage. However, the underlying mechanism remains unclear. This study aimed to explore the changes in succinate levels and identify the mechanisms underlying their contribution...

Mengdi Zhang, Yao Cheng, Yujie Zhai, Yaru Cui, Wenshen Zhang… in Cell Death Discovery (2022)

Article

Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE

Yinghui Wei, Chunlong Xu, Hu Feng, Kui Xu, Zhifang Li, **g Hu, Ling Zhou… in Cell Discovery (2022)