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Article
Association of folate and alcohol with risk of ovarian cancer in a prospective study of postmenopausal women
Studies evaluating the association of ovarian cancer with alcohol intake are inconsistent, and few have evaluated this association in the context of folate consumption. Dietary folate and alcohol intakes and l...
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Article
Vegetables- and antioxidant-related nutrients, genetic susceptibility, and non-Hodgkin lymphoma risk
Genetic susceptibility to DNA oxidation, carcinogen metabolism, and altered DNA repair may increase non-Hodgkin lymphoma (NHL) risk, whereas vegetables- and antioxidant-related nutrients may decrease risk. We ...
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Article
Can genes for mammographic density inform cancer aetiology?
High mammographic density (MD) is an established risk factor for breast cancer. In theory, the number of genes that regulate MD should be smaller than that influencing breast cancer risk. How informative have ...
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Article
Open AccessGenetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies
The stroma is the supportive framework of biologic tissue in the breast, consisting of various proteins such as the proteoglycans, decorin and lumican. Altered expression of decorin and lumican is associated w...
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Article
Open AccessPolymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian Cancer
The nuclear factor-κB (NF-κB) family is a set of transcription factors with key roles in the induction of the inflammatory response and may be the link between inflammation and cancer development. This pathway...
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Article
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
Simon Gayther and colleagues report a genome wide association study for ovarian cancer. They identify two new susceptibility loci at 2q31 and 8q24 and two suggestive susceptibility loci at 3q25 and 17q21.
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Article
Common variants at 19p13 are associated with susceptibility to ovarian cancer
Paul Pharoah and colleagues report a genome-wide association study for survival time after diagnosis of epithelial ovarian cancer and a parallel analysis of susceptibility to epithelial ovarian cancer. They id...
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Article
Open AccessLinkage analysis of obesity phenotypes in pre- and post-menopausal women from a United States mid-western population
Obesity has a strong genetic influence, with some variants showing stronger associations among women than men. Women are also more likely to distribute weight in the abdomen following menopause. We investigate...
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Article
Cohorts and consortia conference: a summary report (Banff, Canada, June 17–19, 2009)
Epidemiologic studies have adapted to the genomics era by forming large international consortia to overcome issues of large data volume and small sample size. Whereas both cohort and well-conducted case–contro...
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Article
Open AccessRecent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium
Studies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, l...
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Article
Open AccessIdentification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31
Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that varian...
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Article
Open AccessEpigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer
HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially as...
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Article
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer
Paul Pharoah, Joellen Schildkraut, Thomas Sellers and colleagues report a meta-analysis of genome-wide association studies for epithelial ovarian cancer and genoty** using the iCOGS array in 18,174 cases and...
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Article
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations ...
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Article
Open AccessLinear combination test for gene set analysis of a continuous phenotype
Gene set analysis (GSA) methods test the association of sets of genes with a phenotype in gene expression microarray studies. Many GSA methods have been proposed, especially methods for use with a binary pheno...
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Article
Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA
Epithelial ovarian cancer (EOC) is a heterogeneous cancer with both genetic and environmental risk factors. Variants influencing the risk of develo** the less-common EOC subtypes have not been fully investi...
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Article
Identification of six new susceptibility loci for invasive epithelial ovarian cancer
Georgia Chenevix-Trench and colleagues report meta-analyses of genome-wide association studies identifying six loci newly associated with epithelial ovarian cancer (EOC). They also test variants at the 12 know...
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Article
Open AccessCis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer
Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susce...
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Article
Correction: Corrigendum: Common variants at 19p13 are associated with susceptibility to ovarian cancer
Nat. Genet. 42, 880–884 (2010); published online 19 September 2010; corrected after print 7 December 2015 In the version of this article initially published, the name of author Angela Brooks-Wilson was spelled...
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Article
Open AccessRecreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium
Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to ...
