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  1. Article

    Open Access

    Single Cell Map of Human Azoospermia Testis Caused by Cyclophosphamide Chemotherapy

    Chemotherapeutic drugs will affect the process of spermatogenesis. However, most current studies on the effects of chemotherapeutic drugs on spermatogenesis are based on mouse models, with a shortage of human ...

    Jian Cao, Xueheng Zhao, Zailong Qin, Shanshan Lv, Lin Du, Zhizhong Liu in Scientific Data (2024)

  2. Article

    Open Access

    Growth hormone releasing hormone signaling promotes Th17 cell differentiation and autoimmune inflammation

    Dysregulation of Th17 cell differentiation and pathogenicity contributes to multiple autoimmune and inflammatory diseases. Previously growth hormone releasing hormone receptor (GHRH-R) deficient mice have been...

    Lin Du, Bo Man Ho, Linbin Zhou, Yolanda Wong Ying Yip, **g Na He in Nature Communications (2023)

  3. Article

    Open Access

    A novel data-driven methodology for influenza outbreak detection and prediction

    Influenza is an infectious disease that leads to an estimated 5 million cases of severe illness and 650,000 respiratory deaths worldwide each year. The early detection and prediction of influenza outbreaks are...

    Lin Du, Yan Pang in Scientific Reports (2021)

  4. Article

    Open Access

    Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach

    The taccalonolide microtubule stabilizers covalently bind β-tubulin and overcome clinically relevant taxane resistance mechanisms. Evaluations of the target specificity and detailed drug–target interactions of...

    Lin Du, Samantha S. Yee, Karthik Ramachandran, April L. Risinger in Nature Communications (2020)

  5. Article

    Open Access

    Ring-Size Effects on the Stability and Spectral Shifts of Hydrogen Bonded Cyclic Ethers Complexes

    In order to investigate ring-size effects on the stability and spectral shifts of hydrogen bonded cyclic ethers complexes, the strength of hydrogen bonds in gas phase complexes formed between 2,2,2-trifluoroet...

    Shanshan Tang, Narcisse T. Tsona, Lin Du in Scientific Reports (2018)

  6. Article

    Open Access

    Selectivity of Cobalt Corrole for CO vs. O2 and N2 in Indoor Pollution

    Coal combustion causes indoor pollution of CO. In this work, DFT calculations on cobalt corrole (Co(Cor)) with three most common indoor gas molecules (N2, O2 and CO) were performed. The Mulliken spin densities sh...

    **a Sheng, Hailiang Zhao, Lin Du in Scientific Reports (2017)

  7. Article

    Open Access

    The Influence of the Position of the Double Bond and Ring Size on the Stability of Hydrogen Bonded Complexes

    To study the influence of the position of the double bond and ring size on the stability of hydrogen bonded complexes, the 1:1 complexes formed between 2,2,2-trifluoroethanol (TFE) and three heterocyclic compo...

    Shumin Cheng, Shanshan Tang, Narcisse T. Tsona, Lin Du in Scientific Reports (2017)

  8. Article

    Open Access

    Evaluation of hyperspectral LiDAR for monitoring rice leaf nitrogen by comparison with multispectral LiDAR and passive spectrometer

    Fast and nondestructive assessment of leaf nitrogen concentration (LNC) is critical for crop growth diagnosis and nitrogen management guidance. In the last decade, multispectral LiDAR (MSL) systems have promot...

    Jia Sun, Shuo Shi, Wei Gong, Jian Yang, Lin Du, Shalei Song in Scientific Reports (2017)

  9. Article

    Open Access

    Analyzing the performance of fluorescence parameters in the monitoring of leaf nitrogen content of paddy rice

    Leaf nitrogen content (LNC) is a significant factor which can be utilized to monitor the status of paddy rice and it requires a reliable approach for fast and precise quantification. This investigation aims to...

    Jian Yang, Wei Gong, Shuo Shi, Lin Du, Jia Sun, Shalei Song in Scientific Reports (2016)

  10. Article

    Open Access

    Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke

    We previously reported neuroprotective activity of the botanical anti-cancer drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, in brain slice and in vivo models of ischemic stroke. We show...

    Michael J. Van Kanegan, Denise E. Dunn, Linda S. Kaltenbach in Scientific Reports (2016)

  11. Article

    Open Access

    Component fractionation of wood-tar by column chromatography with the packing material of silica gel

    Bio-oil can be an important fuel resource for automobiles in the future, while its complex composition restricts the direct application of the bio-oil extremely. So it is necessary to separate the complex mixt...

    Ze Wang, WeiGang Lin, WenLi Song, Lin Du, ZhengJie Li in Chinese Science Bulletin (2011)

  12. No Access

    Article

    Smog chamber studies of ozone formation potentials for isopentane

    The incremental reactivity and ozone formation potential of isopentane have been studied with chamber experiments and computer simulations. The chemical mechanism used in the computer simulations is an isopent...

    Long Jia, YongFu Xu, MaoFa Ge, Lin Du, GuoShun Zhuang in Chinese Science Bulletin (2009)

  13. No Access

    Article

    Rate constants for the reaction of ozone with n-butyl, s-butyl and t-butyl methyl sulfides

    The rate constants for the ozone reactions with n-butyl methyl sulfide (n-BMS, CH3CH2CH2CH2SCH3), sec-butyl methyl sulfide (s-BMS, CH3CH2(CH3)CHSCH3) and tert-butyl methyl sulfide (t-BMS, (CH3)3CSCH3) were measur...

    Kun Wang, Lin Du, MaoFa Ge in Chinese Science Bulletin (2008)

  14. No Access

    Article

    Experimental and theoretical studies of the reaction between cationic vanadium oxide clusters and acetylene

    The time of flight mass spectrometer coupled with a laser ablation/supersonic expansion cluster source and a fast flow reactor was adopted to study the reactivity of cationic vanadium oxide clusters (V ...

    Shi Yin, Yan** Ma, Lin Du, ShengGui He, MaoFa Ge in Chinese Science Bulletin (2008)

  15. No Access

    Article

    Experimental investigation of incremental reactivity of di-tert-butyl peroxide

    Large quantities of di-tert-butyl peroxide (DTBP) have been emitted into the troposphere due to human activities. Its role in the atmospheric photochemical reaction has not been understood. This study presents th...

    Lin Du, YongFu Xu, MaoFa Ge, Long Jia, Li Yao in Chinese Science Bulletin (2007)

  16. No Access

    Article

    A kinetic study of the reaction of ozone with ethylene in a smog chamber under atmospheric conditions

    Ozone is one of the key species in the processes of atmospheric chemistry, which can be taken as an indicator of oxidation capacity in the troposphere. The reaction of ozone with reactive gases is an important...

    Yongfu Xu, Long Jia, Maofa Ge, Lin Du, Gengchen Wang in Chinese Science Bulletin (2006)