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Article
Open AccessSingle Cell Map of Human Azoospermia Testis Caused by Cyclophosphamide Chemotherapy
Chemotherapeutic drugs will affect the process of spermatogenesis. However, most current studies on the effects of chemotherapeutic drugs on spermatogenesis are based on mouse models, with a shortage of human ...
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Article
Open AccessGrowth hormone releasing hormone signaling promotes Th17 cell differentiation and autoimmune inflammation
Dysregulation of Th17 cell differentiation and pathogenicity contributes to multiple autoimmune and inflammatory diseases. Previously growth hormone releasing hormone receptor (GHRH-R) deficient mice have been...
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Article
Open AccessA novel data-driven methodology for influenza outbreak detection and prediction
Influenza is an infectious disease that leads to an estimated 5 million cases of severe illness and 650,000 respiratory deaths worldwide each year. The early detection and prediction of influenza outbreaks are...
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Article
Open AccessElucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach
The taccalonolide microtubule stabilizers covalently bind β-tubulin and overcome clinically relevant taxane resistance mechanisms. Evaluations of the target specificity and detailed drug–target interactions of...
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Article
Open AccessRing-Size Effects on the Stability and Spectral Shifts of Hydrogen Bonded Cyclic Ethers Complexes
In order to investigate ring-size effects on the stability and spectral shifts of hydrogen bonded cyclic ethers complexes, the strength of hydrogen bonds in gas phase complexes formed between 2,2,2-trifluoroet...
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Article
Open AccessSelectivity of Cobalt Corrole for CO vs. O2 and N2 in Indoor Pollution
Coal combustion causes indoor pollution of CO. In this work, DFT calculations on cobalt corrole (Co(Cor)) with three most common indoor gas molecules (N2, O2 and CO) were performed. The Mulliken spin densities sh...
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Article
Open AccessThe Influence of the Position of the Double Bond and Ring Size on the Stability of Hydrogen Bonded Complexes
To study the influence of the position of the double bond and ring size on the stability of hydrogen bonded complexes, the 1:1 complexes formed between 2,2,2-trifluoroethanol (TFE) and three heterocyclic compo...
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Article
Open AccessEvaluation of hyperspectral LiDAR for monitoring rice leaf nitrogen by comparison with multispectral LiDAR and passive spectrometer
Fast and nondestructive assessment of leaf nitrogen concentration (LNC) is critical for crop growth diagnosis and nitrogen management guidance. In the last decade, multispectral LiDAR (MSL) systems have promot...
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Article
Open AccessAnalyzing the performance of fluorescence parameters in the monitoring of leaf nitrogen content of paddy rice
Leaf nitrogen content (LNC) is a significant factor which can be utilized to monitor the status of paddy rice and it requires a reliable approach for fast and precise quantification. This investigation aims to...
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Article
Open AccessDual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke
We previously reported neuroprotective activity of the botanical anti-cancer drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, in brain slice and in vivo models of ischemic stroke. We show...
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Article
Open AccessComponent fractionation of wood-tar by column chromatography with the packing material of silica gel
Bio-oil can be an important fuel resource for automobiles in the future, while its complex composition restricts the direct application of the bio-oil extremely. So it is necessary to separate the complex mixt...
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Article
Smog chamber studies of ozone formation potentials for isopentane
The incremental reactivity and ozone formation potential of isopentane have been studied with chamber experiments and computer simulations. The chemical mechanism used in the computer simulations is an isopent...
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Article
Rate constants for the reaction of ozone with n-butyl, s-butyl and t-butyl methyl sulfides
The rate constants for the ozone reactions with n-butyl methyl sulfide (n-BMS, CH3CH2CH2CH2SCH3), sec-butyl methyl sulfide (s-BMS, CH3CH2(CH3)CHSCH3) and tert-butyl methyl sulfide (t-BMS, (CH3)3CSCH3) were measur...
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Article
Experimental and theoretical studies of the reaction between cationic vanadium oxide clusters and acetylene
The time of flight mass spectrometer coupled with a laser ablation/supersonic expansion cluster source and a fast flow reactor was adopted to study the reactivity of cationic vanadium oxide clusters (V ...
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Article
Experimental investigation of incremental reactivity of di-tert-butyl peroxide
Large quantities of di-tert-butyl peroxide (DTBP) have been emitted into the troposphere due to human activities. Its role in the atmospheric photochemical reaction has not been understood. This study presents th...
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Article
A kinetic study of the reaction of ozone with ethylene in a smog chamber under atmospheric conditions
Ozone is one of the key species in the processes of atmospheric chemistry, which can be taken as an indicator of oxidation capacity in the troposphere. The reaction of ozone with reactive gases is an important...