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Article
Open AccessA gamepad-like nucleic acid testing device for rapid detection of SARS-CoV-2 via visible nested recombinase polymerase amplification
Nucleic acid tests are essential for the accurate diagnosis and control of infectious diseases. However, current assays are not easily scalable for a large population, due to the requirement of laboratory sett...
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Article
Open AccessHighly diverse sputum microbiota correlates with the disease severity in patients with community-acquired pneumonia: a longitudinal cohort study
Community-acquired pneumonia (CAP) is a common and serious condition that can be caused by a variety of pathogens. However, much remains unknown about how these pathogens interact with the lower respiratory co...
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Article
Open AccessPlasma proteome profiling reveals dynamic of cholesterol marker after dual blocker therapy
Dual blocker therapy (DBT) has the enhanced antitumor benefits than the monotherapy. Yet, few effective biomarkers are developed to monitor the therapy response. Herein, we investigate the DBT longitudinal pla...
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Article
Discovery of tumor-reactive T cell receptors by massively parallel library synthesis and screening
T cell receptor (TCR) gene therapy is a potent form of cellular immunotherapy in which patient T cells are genetically engineered to express TCRs with defined tumor reactivity. However, the isolation of therap...
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Article
Dynamic Event-Triggered Adaptive Fixed-Time Fuzzy Tracking Control for Stochastic Nonlinear Systems Under Asymmetric Time-Varying State Constraints
In this article, an adaptive fixed-time tracking control scheme is investigated for stochastic nonlinear systems with asymmetric time-varying state constraints based on the dynamic event-triggered control (DET...
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Article
Open AccessMETTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation
While liver cancer stem cells (CSCs) play a crucial role in hepatocellular carcinoma (HCC) initiation, progression, recurrence, and treatment resistance, the mechanism underlying liver CSC self-renewal remains...
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Article
Open AccessMSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation
Sensorineural hearing loss (SNHL) poses a major threat to both physical and mental health; however, there is still a lack of effective drugs to treat the disease. Recently, novel biological therapies, such as ...
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Article
Open AccessRelationship between glucocorticoids and viral load during the Omicron wave in mainland China
Coronavirus disease 19 (COVID-19) is a major public health problem that cannot be ignored. As a widely used drug in the treatment of COVID-19, whether glucocorticoids may accelerate the clearance of COVID-19 i...
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Article
Open AccessAerosols overtake greenhouse gases causing a warmer climate and more weather extremes toward carbon neutrality
To mitigate climate warming, many countries have committed to achieve carbon neutrality in the mid-21st century. Here, we assess the global impacts of changing greenhouse gases (GHGs), aerosols, and tropospheric ...
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Article
Fabrication of a porous Co0.85Se/rGO composite for efficient hydrazine oxidation
The development of efficient and earth-abundant catalysts for hydrazine oxidation (HzOR) is of great significance for direct hydrazine fuel cell. In the present study, we report Co0.85Se/rGO electrocatalyst with ...
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Article
Open AccessApplication of human–computer interaction virtual reality technology in urban cultural creative design
As the in-depth expansion and integrated application of information technology, smart city is one of the important directions for nurturing breakthroughs in the new generation of information technology, and an...
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Article
Open AccessPathogenesis diagnosis of a pediatric patient suffering from multi-organ abscesses
A pediatric patient suffered from renal and hepatic abscesses (through hepatorenal space) and recovered by antibiotics and other therapies. By clinical analysis, the multi-organ abscesses might be caused by bl...
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Article
Using Wireless Network Sensors as a New Medium of Communication for Sustainable Eco-cultural Tourism
Internet of Things (IoT) in tourism refers to the use of interconnected devices and systems to enhance the travel experience for tourists. IoT applications in the tourism industry include using and promoting n...
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Article
Electrodeposition of nanoporous Ni0.85Se arrays anchored on rGO promotes high-efficiency oxygen evolution reaction
Highly efficient and low-cost electrocatalyst is much desirable for oxygen evolution reaction (OER) to enhance the water splitting efficiency. In this work, a self-supported nanoporous Ni0.85Se/rGO was electrodep...
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Article
Open AccessZn-MOF hydrogel: regulation of ROS-mediated inflammatory microenvironment for treatment of atopic dermatitis
Atopic dermatitis (AD) is a chronic and recurrent inflammation disease associated with immune dysfunction. The high level of reactive oxygen species (ROS) causes high oxidative stress and further results in th...
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Article
Open AccessIdentification of priority pathogens for aetiological diagnosis in adults with community-acquired pneumonia in China: a multicentre prospective study
Community-acquired pneumonia (CAP) is a major public health challenge worldwide. However, the aetiological and disease severity-related pathogens associated with CAP in adults in China are not well established...
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Article
Analyte-Mediated Peroxidase-Mimicking Activity Enhancement of Cysteine-Capped Silver Nanoparticles for Colorimetric Detection of Copper Ions
A novel and efficient colorimetric assay was developed for the detection of copper ions (Cu2+) in real environmental water based on analyte-mediated peroxidase-mimicking activity enhancement of cysteine-capped si...
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Article
Efficient OER electrocatalyst based on Co0.85Se/rGO nanocomposite
Designing high-performance oxygen evolution reaction (OER) electrocatalysts is critical for water electrolysis. In this work, a self-supported nanoporous structured Co0.85Se/rGO was prepared on Ni foam (NF) durin...
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Article
Regulatory role of melatonin in Notch1 signaling pathway in cerebral cortex of Aβ1−42-induced Alzheimer’s disease rat model
Soluble Amyloid-beta (Aβ) oligomers are thought to play a key role in the pathogenesis of Alzheimer’s disease (AD), which is the most common age-associated neurodegenerative diseases with obvious neuropatholog...
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Article
Open AccessClinical characteristics of central nervous system candidiasis due to Candida albicans in children: a single-center experience
Central nervous system candidiasis due to Candida albicans (CNSC) in children is easily misdiagnosed and is associated with poor outcomes and a high mortality rate. There is no big data research or systematic rev...
