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  1. No Access

    Article

    Characterization of Apolipoprotein C3 (Apo C3) LNA/DNA Impurities and Degradation Products by LC-MS/MS

    Apolipoprotein C3 (Apo C3) LNA/DNA gapmer was evaluated under various stress and formulation conditions for the purpose of its development as a potential biotherapeutic for low density lipoprotein (LDL) loweri...

    Olga V. Friese, Justin B. Sperry, Yan He, Liji Joseph, James A. Carroll… in The AAPS Journal (2017)

  2. No Access

    Article

    Visible and Sub-visible Particle Formation for a Model Bioconjugate

    The time-course and extent of visible particle (VP) and sub-visible particle (SVP) formation was monitored as a function of interfacial area (IA) for a model bioconjugate. To facilitate particle formation, the...

    Lavinia M. Lewis, Michelle E. Pizzo, Sandipan Sinha, Syed S. Ahmed… in AAPS PharmSciTech (2017)

  3. No Access

    Article

    Characterizing the Freeze–Drying Behavior of Model Protein Formulations

    The freeze–drying behavior of three model proteins, namely, lysozyme, BSA, and IgG, has been studied using a variety of techniques under two different primary drying conditions (shelf temperatures of −25°C and...

    Lavinia M. Lewis, Robert E. Johnson, Megan E. Oldroyd, Saleem S. Ahmed… in AAPS PharmSciTech (2010)