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  1. Article

    Open Access

    Harnessing nanomedicine to overcome the immunosuppressive tumor microenvironment

    Cancer immunotherapy has received extensive attention due to its ability to activate the innate or adaptive immune systems of patients to combat tumors. Despite a few clinical successes, further endeavors are ...

    Bo Sun, Hyesun Hyun, Lian-tao Li, Andrew Z Wang in Acta Pharmacologica Sinica (2020)

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  2. No Access

    Article

    Curcumin induces apoptosis through mitochondrial pathway and caspases activation in human melanoma cells

    Melanoma is the most malignant skin cancer and is highly resistant to chemotherapy and radiotherapy. Curcumin is a component of turmeric, the yellow spice derived from the rhizome of Curcuma longa. It has been de...

    Ai-Jun Jiang, Guan Jiang, Lian-Tao Li, Jun-Nian Zheng in Molecular Biology Reports (2015)

  3. No Access

    Article

    Progression of O6-methylguanine-DNA methyltransferase and temozolomide resistance in cancer research

    Temozolomide (TMZ) is an alkylating agent that is widely used in chemotherapy for cancer. A key mechanism of resistance to TMZ is the overexpression of O6-methylguanine-DNA methyltransferase (MGMT). MGMT specific...

    Guan Jiang, Ai-Jun Jiang, Yong **n, Lian-Tao Li, Qian Cheng… in Molecular Biology Reports (2014)

  4. No Access

    Article

    Rap2B promotes migration and invasion of human suprarenal epithelioma

    The aim of our study was to elucidate the role of Rap2B in the development of human suprarenal epithelioma and to investigate the effect of Rap2B on suprarenal epithelioma cells migration and invasion. We use ...

    Jie-Hui Di, De-Bao Qu, Zheng Lu, Lian-Tao Li, Qian Cheng, … in Tumor Biology (2014)

  5. No Access

    Article

    A dual-regulated oncolytic adenovirus expressing interleukin-24 sensitizes melanoma cells to temozolomide via the induction of apoptosis

    Malignant melanoma is one of the most lethal and aggressive human malignancies. Suppressed apoptosis and extraordinary invasiveness are the distinctive features that contribute to malignant melanoma. The alkyl...

    Guan Jiang, Ai-Jun Jiang, Qian Cheng, Hui Tian, Lian-Tao Li… in Tumor Biology (2013)

  6. No Access

    Article

    p53 regulates Ki-67 promoter activity through p53- and Sp1-dependent manner in HeLa cells

    The expression of the human Ki-67 protein, which is strictly associated with cell proliferation, is regulated by a variety of cellular mediators. In this study, we studied the effects of p53 on Ki-67 promoter ...

    Mei-Juan Wang, Dong-Sheng Pei, Guo-Wei Qian, **ao-**ng Yin, Qian Cheng… in Tumor Biology (2011)

  7. No Access

    Article

    The effect of methylated oligonucleotide targeting Ki-67 gene in human 786-0 renal carcinoma cells

    To investigate the effect of methylated oligonucleotide (MON) targeting Ki-67 promoter on the expression of Ki-67 gene and the proliferation and apoptosis of the human 786-0 renal carcinoma cells, human 786-0 ...

    Xue-Qin Li, Dong-Sheng Pei, Guo-Wei Qian, **ao-**ng Yin, Qian Cheng… in Tumor Biology (2011)