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Open AccessSynthetic macrolides overcoming MLSBK-resistant pathogens
Conventional macrolide-lincosamide-streptogramin B-ketolide (MLSBK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...
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Article
Open AccessDistinct properties of putative trophoblast stem cells established from somatic cell nuclear-transferred pig blastocysts
Genetically modified pigs are considered ideal models for studying human diseases and potential sources for xenotransplantation research. However, the somatic cell nuclear transfer (SCNT) technique utilized to...
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Article
Open AccessCEBPB-mediated upregulation of SERPINA1 promotes colorectal cancer progression by enhancing STAT3 signaling
Colorectal cancer (CRC) is a highly malignant carcinoma associated with poor prognosis, and metastasis is one of the most common causes of death in CRC. Serpin Family A Member 1 (SERPINA1) is a serine protease...
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Article
Open AccessGenetic and pharmacological reduction of CDK14 mitigates synucleinopathy
Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-Synuclein (α-Syn) protein. Currently, n...
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Open AccessUBE2O reduces the effectiveness of interferon-α via degradation of IFIT3 in hepatocellular carcinoma
Interferon (IFN) exerts its effects through interferon-stimulated genes (ISGs), but its efficacy is limited by interferon resistance, which can be caused by the ubiquitination of key proteins. UBE2O was initia...
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Open AccessMechanisms of PANoptosis and relevant small-molecule compounds for fighting diseases
Pyroptosis, apoptosis, and necroptosis are mainly programmed cell death (PCD) pathways for host defense and homeostasis. PANoptosis is a newly distinct inflammatory PCD pathway that is uniquely regulated by mu...
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Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation
The prolyl hydroxylation of hypoxia-inducible factor 1α (HIF-1α) mediated by the EGLN–pVHL pathway represents a classic signalling mechanism that mediates cellular adaptation under hypoxia. Here we identify RI...
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Article
Omentin-1 drives cardiomyocyte cell cycle arrest and metabolic maturation by interacting with BMP7
Mammalian cardiomyocytes (CMs) undergo maturation during postnatal heart development to meet the increased demands of growth. Here, we found that omentin-1, an adipokine, facilitates CM cell cycle arrest and m...
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Open AccessPHF14 enhances DNA methylation of SMAD7 gene to promote TGF-β-driven lung adenocarcinoma metastasis
Aberrant activation of TGF-β signaling plays a pivotal role in cancer metastasis and progression. However, molecular mechanisms underlying the dysregulation of TGF-β pathway remain to be understood. Here, we f...
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Open AccessThe role of integrin family in bone metabolism and tumor bone metastasis
Integrins have been the research focus of cell-extracellular matrix adhesion (ECM) and cytokine receptor signal transduction. They are involved in the regulation of bone metabolism of bone precursor cells, mes...
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Article
Open AccessTRIM56 acts through the IQGAP1-CDC42 signaling axis to promote glioma cell migration and invasion
Diffuse invasion is an important factor leading to treatment resistance and a poor prognosis in gliomas. Herein, we found that expression of the tripartite motif containing 56 (TRIM56), a RING-finger domain co...
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Article
Open AccessmiR579-3p is an inhibitory modulator of neointimal hyperplasia and transcription factors c-MYB and KLF4
Neointimal hyperplasia (IH) is a common vascular pathology that typically manifests in in-stent restenosis and bypass vein graft failure. Smooth muscle cell (SMC) phenotypic switching is central to IH, both re...
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Open AccessMiR-7-5p/KLF4 signaling inhibits stemness and radioresistance in colorectal cancer
Resistance to radiotherapy remains a major unmet clinical obstacle in the treatment of locally advanced rectal cancer. Cancer stem cells (CSCs) are considered to mediate tumor development and radioresistance. ...
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Open AccessTargeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma
Anillin (ANLN) is a mitosis-related protein that promotes contractile ring formation and cytokinesis, but its cell cycle-dependent degradation mechanisms in cancer cells remain unclear. Here, we show that high...
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Open AccessRegulation of KDM5C stability and enhancer reprogramming in breast cancer
Abnormality of enhancer regulation has emerged as one of the critical features for cancer cells. KDM5C is a histone H3K4 demethylase and frequently mutated in several types of cancer. It is critical for H3K4me...
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Open AccessA dual Keap1 and p47phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis
Oxidative stress is a vital contributor to the development and progression of diabetes-accelerated atherosclerosis. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a well-known molecule that participates...
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Open AccessLIGHT deficiency attenuates acute kidney disease development in an in vivo experimental renal ischemia and reperfusion injury model
Ischemia-reperfusion (I/R), a leading risk factor of acute kidney injury (AKI), is associated with high mortality and risk of progression to chronic kidney disease. However, the molecular mechanism of I/R-AKI ...
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Open AccessCorrection: miR548ai antagonism attenuates exosome-induced endothelial cell dysfunction
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Open AccessArtificial intelligence defines protein-based classification of thyroid nodules
Determination of malignancy in thyroid nodules remains a major diagnostic challenge. Here we report the feasibility and clinical utility of develo** an AI-defined protein-based biomarker panel for diagnostic...
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Potential antibacterial and anti-biofilm effects of Anoectochilus roxburghii rhizome cultures
Anoectochilus roxburghii (Wall.) Lindl. is a precious herb plant and its rhizome cultures can be used as an alternative plant material. To utilize rhizomes in practical production, this study investigated the ant...