59 Result(s)

Article

CEBPB-mediated upregulation of SERPINA1 promotes colorectal cancer progression by enhancing STAT3 signaling

Colorectal cancer (CRC) is a highly malignant carcinoma associated with poor prognosis, and metastasis is one of the most common causes of death in CRC. Serpin Family A Member 1 (SERPINA1) is a serine protease...

Yiming Ma, Ying Chen, Lei Zhan, Qian Dong, Yuanhe Wang, **aoyan Li… in Cell Death Discovery (2024)

Article

Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy

Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-Synuclein (α-Syn) protein. Currently, n...

Jean-Louis A. Parmasad, Konrad M. Ricke, Benjamin Nguyen… in Cell Death & Disease (2024)

Article

UBE2O reduces the effectiveness of interferon-α via degradation of IFIT3 in hepatocellular carcinoma

Interferon (IFN) exerts its effects through interferon-stimulated genes (ISGs), but its efficacy is limited by interferon resistance, which can be caused by the ubiquitination of key proteins. UBE2O was initia...

Heng Li, Yao Liu, Can Cheng, Yang Wu, Shu-Hang Liang, Liang Wu… in Cell Death & Disease (2023)

Article

Mechanisms of PANoptosis and relevant small-molecule compounds for fighting diseases

Pyroptosis, apoptosis, and necroptosis are mainly programmed cell death (PCD) pathways for host defense and homeostasis. PANoptosis is a newly distinct inflammatory PCD pathway that is uniquely regulated by mu...

Lian Wang, Yanghui Zhu, Lu Zhang, Linghong Guo, … in Cell Death & Disease (2023)

Article

The role of integrin family in bone metabolism and tumor bone metastasis

Integrins have been the research focus of cell-extracellular matrix adhesion (ECM) and cytokine receptor signal transduction. They are involved in the regulation of bone metabolism of bone precursor cells, mes...

Liwei Mao, Lian Wang, Jiake Xu, Jun Zou in Cell Death Discovery (2023)

Article

TRIM56 acts through the IQGAP1-CDC42 signaling axis to promote glioma cell migration and invasion

Diffuse invasion is an important factor leading to treatment resistance and a poor prognosis in gliomas. Herein, we found that expression of the tripartite motif containing 56 (TRIM56), a RING-finger domain co...

Qing Zhang, Jianglin Zheng, Wenjie Wu, Haiyan Lian, Natasha Iranzad… in Cell Death & Disease (2023)

Article

miR579-3p is an inhibitory modulator of neointimal hyperplasia and transcription factors c-MYB and KLF4

Neointimal hyperplasia (IH) is a common vascular pathology that typically manifests in in-stent restenosis and bypass vein graft failure. Smooth muscle cell (SMC) phenotypic switching is central to IH, both re...

**ujie **e, Takuro Shirasu, **g Li, Lian-Wang Guo, K. Craig Kent in Cell Death Discovery (2023)

Article

MiR-7-5p/KLF4 signaling inhibits stemness and radioresistance in colorectal cancer

Resistance to radiotherapy remains a major unmet clinical obstacle in the treatment of locally advanced rectal cancer. Cancer stem cells (CSCs) are considered to mediate tumor development and radioresistance. ...

Yuanyuan Shang, Zhe Zhu, Yuanyuan Zhang, Fang Ji, Lian Zhu… in Cell Death Discovery (2023)

Article

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Anillin (ANLN) is a mitosis-related protein that promotes contractile ring formation and cytokinesis, but its cell cycle-dependent degradation mechanisms in cancer cells remain unclear. Here, we show that high...

Yu-Fei Cao, Lei **e, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi… in Cell Death & Differentiation (2023)

Article

Regulation of KDM5C stability and enhancer reprogramming in breast cancer

Abnormality of enhancer regulation has emerged as one of the critical features for cancer cells. KDM5C is a histone H3K4 demethylase and frequently mutated in several types of cancer. It is critical for H3K4me...

Qiong **ao, Chen-Yu Wang, Chuan Gao, Ji-Dong Chen, **g-**g Chen… in Cell Death & Disease (2022)

Article

A dual Keap1 and p47^phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis

Oxidative stress is a vital contributor to the development and progression of diabetes-accelerated atherosclerosis. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a well-known molecule that participates...

Zi-Chao Wang, Kai-Ming Niu, Yu-Jie Wu, Kai-Rui Du, Lian-Wen Qi… in Cell Death & Disease (2022)

Article

LIGHT deficiency attenuates acute kidney disease development in an in vivo experimental renal ischemia and reperfusion injury model

Ischemia-reperfusion (I/R), a leading risk factor of acute kidney injury (AKI), is associated with high mortality and risk of progression to chronic kidney disease. However, the molecular mechanism of I/R-AKI ...

Quan-you Zheng, You Li, Shen-ju Liang, **-ming Chen, Ming Tang… in Cell Death Discovery (2022)

Article

Correction: miR548ai antagonism attenuates exosome-induced endothelial cell dysfunction

**ujie **e, Lian-Wang Guo, Craig K. Kent in Cell Death Discovery (2022)

Article

Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There i...

Meng Kou, Li Huang, **juan Yang, Zhixin Chiang, Shaoxiang Chen… in Cell Death & Disease (2022)

Article

IDO1 plays a tumor-promoting role via MDM2-mediated suppression of the p53 pathway in diffuse large B-cell lymphoma

With the intensive therapeutic strategies, diffuse large B-cell lymphoma (DLBCL) is still a fatal disease due to its progressive characteristics. Indoleamine 2,3-dioxygenase 1 (IDO1) is a key regulator that ca...

Chengtao Sun, Mengzhen Li, Lian Zhang, Feifei Sun, Huimou Chen… in Cell Death & Disease (2022)

Article

Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the world’s leading causes of death, and its primary clinical therapy relies on surgical resection, chemotherapy, radiotherapy, and chemoradiotherapy. Althou...

Zhen-Yuan Zheng, Man-Yu Chu, Wan Lin, Ya-Qi Zheng, **u-E Xu… in Cell Death & Disease (2022)

Article

m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer

LHPP, a histidine phosphatase, has been implicated in tumour progression. However, its role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are elusive. Here, we obtained GC ti...

Jian-**an Lin, Ning-Zi Lian, You-**n Gao, Qiao-Ling Zheng… in Cell Death & Disease (2022)

Article

Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation

Many integral membrane proteins might act as indispensable coordinators in specific functional microdomains to maintain the normal operation of known receptors, such as Notch. Gm364 is a multi-pass transmembra...

Liang-Jian Chen, Na-Na Zhang, Chun-**ang Zhou, Zhi-**a Yang… in Cell Death & Differentiation (2022)

Article

Advances in the pathogenesis of psoriasis: from keratinocyte perspective

Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we rev...

Xue Zhou, Youdong Chen, Lian Cui, Yuling Shi, Chunyuan Guo in Cell Death & Disease (2022)