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  1. No Access

    Article

    Adenine base-editing-mediated exon skip** induces gene knockout in cultured pig cells

    Gene-knockout pigs have important applications in agriculture and medicine. Compared with CRISPR/Cas9, Adenine base editor (ABE) convert single A·T pairs to G·C pairs in the genome without generating DNA doubl...

    **ang-xing Zhu, Jia-sheng Pan, Tao Lin, Ye-cheng Yang… in Biotechnology Letters (2022)

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    Article

    Application of the modified cytosine base-editing in the cultured cells of bama minipig

    Bama minipig is a unique miniature swine bred from China. Their favorable characteristics include delicious meat, strong adaptability, tolerance to rough feed, and high levels of stress tolerance. Unfavorable ...

    Jia-sheng Pan, Zi-sheng Lin, Jian-cong Wen, Jian-feng Guo… in Biotechnology Letters (2021)

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    Article

    Efficient CRISPR/Cas9-mediated gene editing in Guangdong small-ear spotted pig cells using an optimized electrotransfection method

    Guangdong Small-ear Spotted (GDSS) pigs are a pig breed native to China that possesses unfortunate disadvantages, such as slow growth rate, low lean-meat percentage, and reduced feed utilization. In contrast t...

    Yan-yan Wei, Qun-mei Zhan, **ang-xing Zhu, Ai-fen Yan, Juan Feng… in Biotechnology Letters (2020)