208 Result(s)
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Article
Open AccessEnhancing efficiency of protein language models with minimal wet-lab data through few-shot learning
Accurately modeling the protein fitness landscapes holds great importance for protein engineering. Pre-trained protein language models have achieved state-of-the-art performance in predicting protein fitness w...
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Open AccessEngineering ZrO2–Ru interface to boost Fischer-Tropsch synthesis to olefins
Understanding the structures and reaction mechanisms of interfacial active sites in the Fisher-Tropsch synthesis reaction is highly desirable but challenging. Herein, we show that the ZrO2-Ru interface could be e...
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Open AccessDevelopment and validation of radiomics nomogram for metastatic status of epithelial ovarian cancer
To develop and validate an enhanced CT-based radiomics nomogram for evaluating preoperative metastasis risk of epithelial ovarian cancer (EOC). One hundred and nine patients with histologically confirmed EOC w...
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Open AccessFunctional and structural dissection of glycosyltransferases underlying the glycodiversity of wolfberry-derived bioactive ingredients lycibarbarspermidines
Lycibarbarspermidines are unusual phenolamide glycosides characterized by a dicaffeoylspermidine core with multiple glycosyl substitutions, and serve as a major class of bioactive ingredients in the wolfberry....
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Open AccessExploring the mechanism of **lida granules against type 2 diabetes mellitus by an integrative pharmacology strategy
**lida granule (JLD) is a Traditional Chinese Medicine (TCM) formula used for the treatment of type 2 diabetes mellitus (T2DM). However, the mechanism of JLD treatment for T2DM is not fully revealed. In this ...
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Open AccessCharacteristics of germline DNA damage response gene mutations in ovarian cancer in Southwest China
DNA damage response (DDR) pathways are responsible for repairing endogenous or exogenous DNA damage to maintain the stability of the cellular genome, including homologous recombination repair (HRR) pathway, mi...
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Open AccessSurface hydrophobization of zeolite enables mass transfer matching in gas-liquid-solid three-phase hydrogenation under ambient pressure
Attaining high hydrogenation performance under mild conditions, especially at ambient pressure, remains a considerable challenge due to the difficulty in achieving efficient mass transfer at the gas-liquid-sol...
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Open AccessPrediction of heavy-section ductile iron fracture toughness based on machine learning
The preparation process and composition design of heavy-section ductile iron are the key factors affecting its fracture toughness. These factors are challenging to address due to the long casting cycle, high c...
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Open AccessSystematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3
Progesterone and AdipoQ Receptor 3 (PAQR3) is a member of the AdipoQ receptor. Our previous studies have found that PAQR3 plays a role as a candidate inhibitor in cardiac adenocarcinoma, breast cancer, gastric...
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Article
Open AccessPeriodontitis was associated with mesial concavity of the maxillary first premolar: a cross-sectional study
The association between the anatomical features of teeth and the pathogenesis of periodontitis is well-documented. This study aimed to evaluate the influence of the mesial concavity of the maxillary first prem...
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Open AccessA new high-resolution global topographic factor dataset calculated based on SRTM
Topography is an important factor affecting soil erosion and is measured as a combination of the slope length and slope steepness (LS-factor) in erosion models, like the Chinese Soil Loss Equation. However, gl...
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Open AccessDischarge protocol in acute pancreatitis: an international survey and cohort analysis
There are several overlap** clinical practice guidelines in acute pancreatitis (AP), however, none of them contains suggestions on patient discharge. The Hungarian Pancreatic Study Group (HPSG) has recently ...
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Open AccessAcute kidney injury interacts with VKORC1 genotype on initiative warfarin dose among heart surgery recipients: a real-world research
Patients who receive heart valve surgery need anticoagulation prophylaxis to reduce the risk of thrombosis. Warfarin often is a choice but its dosage varies due to gene and clinical factors. We aim to study, a...
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Open AccessThe ELAVL3/MYCN positive feedback loop provides a therapeutic target for neuroendocrine prostate cancer
Neuroendocrine prostate cancer is a rapidly progressive and lethal disease characterized by early visceral metastasis, poor prognosis, and limited treatment options. Uncovering the oncogenic mechanisms could l...
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Open AccessWall thickness analysis method for judging the degree of lower extremity long bone healing
To evaluate the possibility of judging the degree of bone healing by wall thickness analysis provide reference for quantitative analysis of bone healing. Patients with lower limb fracture from April 2014 to Oc...
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Open AccessBacterial genome size and gene functional diversity negatively correlate with taxonomic diversity along a pH gradient
Bacterial gene repertoires reflect adaptive strategies, contribute to ecosystem functioning and are limited by genome size. However, gene functional diversity does not necessarily correlate with taxonomic dive...
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Open AccessTripartite motif containing 26 prevents steatohepatitis progression by suppressing C/EBPδ signalling activation
Currently potential preclinical drugs for the treatment of nonalcoholic steatohepatitis (NASH) and NASH-related pathopoiesis have failed to achieve expected therapeutic efficacy due to the complexity of the pa...
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Open AccessThin lamellar films with enhanced mechanical properties for durable radiative cooling
Passive daytime radiative cooling is a promising path to tackle energy, environment and security issues originated from global warming. However, the contradiction between desired high solar reflectivity and ne...
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Open AccessSelf-patterning of human stem cells into post-implantation lineages
Investigating human development is a substantial scientific challenge due to the technical and ethical limitations of working with embryonic samples. In the face of these difficulties, stem cells have provided...
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Open AccessDesigning nanohesives for rapid, universal, and robust hydrogel adhesion
Nanoparticles-based glues have recently been shown with substantial potential for hydrogel adhesion. Nevertheless, the transformative advance in hydrogel-based application places great challenges on the rapidi...
