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  1. No Access

    Article

    Scutellarin suppresses triple-negative breast cancer metastasis by inhibiting TNFα-induced vascular endothelial barrier breakdown

    Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with high vascularity and frequent metastasis. Tumor-associated abnormal vasculature was reported to accelerate TNBC metastasis. S...

    **-yu Mei, **g-nan Zhang, Wang-ya Jia, Bin Lu, Meng-na Wang… in Acta Pharmacologica Sinica (2022)

  2. No Access

    Article

    Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway

    Toosendanin (TSN) is the main active compound in Toosendan Fructus and Meliae Cortex, two commonly used traditional Chinese medicines. TSN has been reported to induce hepatotoxicity, but its mechanism remains ...

    Yao **, Zhen-lin Huang, Li Li, Yang Yang, Chang-hong Wang… in Acta Pharmacologica Sinica (2019)

  3. Article

    Chlorogenic acid prevents acetaminophen-induced liver injury: The involvement of CYP450 metabolic enzymes and some antioxidant signals

    Chlorogenic acid (CGA), a polyphenolic compound, is abundant in fruits, dietary vegetables, and some medicinal herbs. This study investigated the prevention of CGA against acetaminophen (AP)-induced hepatotoxi...

    Chun Pang, Yu-chen Sheng, ** Jiang, Hai Wei… in Journal of Zhejiang University-SCIENCE B (2015)

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  4. Article

    Therapeutic detoxification of quercetin against carbon tetrachloride-induced acute liver injury in mice and its mechanism

    This study observes the therapeutic detoxification of quercetin, a well-known flavonoid, against carbon tetrachloride (CCl4) induced acute liver injury in vivo and explores its mechanism. Quercetin decreased CCl4

    Jia-qi Zhang, Liang Shi, **-ning Xu… in Journal of Zhejiang University SCIENCE B (2014)

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  5. Article

    Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo

    The present study is designed to investigate the protection by ferulic acid against the hepato-toxicity induced by diosbulbin B and its possible mechanism, and further observe whether ferulic acid augments dio...

    Jun-ming Wang, Yu-chen Sheng, Li-li Ji… in Journal of Zhejiang University-SCIENCE B (2014)

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  6. No Access

    Article

    The difference of glutathione antioxidant system in newly weaned and young mice liver and its involvement in isoline-induced hepatotoxicity

    Cellular glutathione antioxidant system plays important roles in counteracting hepatotoxins-induced oxidative stress injury. The present study was designed to observe the differences of this system in newly we...

    Qing-Ning Liang, Yu-Chen Sheng, ** Jiang, Li-Li Ji, Yu-Ye **a… in Archives of Toxicology (2011)