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Article
Oncoprotein LAMTOR5-mediated CHOP silence via DNA hypermethylation and miR-182/miR-769 in promotion of liver cancer growth
C/EBP homologous protein (CHOP) triggers the death of multiple cancers via endoplasmic reticulum (ER) stress. However, the function and regulatory mechanism of CHOP in liver cancer remain elusive. We have reporte...
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Article
HBXIP induces PARP1 via WTAP-mediated m6A modification and CEBPA-activated transcription in cisplatin resistance to hepatoma
Poly (ADP-ribose) polymerase 1 (PARP1) is a DNA-binding protein that is involved in various biological functions, including DNA damage repair and transcription regulation. It plays a crucial role in cisplatin ...
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Article
Open AccessIodine-125 seed inhibits proliferation and promotes apoptosis of cholangiocarcinoma cells by inducing the ROS/p53 axis
With advances in radioactive particle implantation in clinical practice, Iodine-125 (125I) seed brachytherapy has emerged as a promising treatment for cholangiocarcinoma (CCA), showing good prognosis; however, th...
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Article
Open AccessComparison of Thoracoscopy-Guided Thoracic Paravertebral Block and Ultrasound-Guided Thoracic Paravertebral Block in Postoperative Analgesia of Thoracoscopic Lung Cancer Radical Surgery: A Randomized Controlled Trial
Ultrasound-guided thoracic paravertebral block (UTPB) is widely used for postoperative analgesia in thoracic surgery. However, it has many disadvantages. Thoracoscopy-guided thoracic paravertebral block (TTPB)...
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Article
Antitumor Effect of Apcin on Endometrial Carcinoma via p21-Mediated Cell Cycle Arrest and Apoptosis
Endometrial carcinoma (EC) is a prevalent gynecological malignancy characterized by increasing incidence and mortality rates. This underscores the critical need for novel therapeutic targets. One such potentia...
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Article
LVNet: A lightweight volumetric convolutional neural network for real-time and high-performance recognition of 3D objects
The 3D object recognition has become one of hot topics in computer vision with the increasing of application scenarios of 3D data, such as robotic systems, autonomous driving, and security check systems using ...
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Article
The influence of biological sex in human skeletal muscle transcriptome during ageing
Sex is a crucial biological variable, and influence of biological sex on the change of gene expression in ageing skeletal muscle has not yet been fully revealed. In this study, the mRNA expression profiles wer...
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Article
Efficacy of chidamide maintenance therapy versus autologous stem cell transplantation versus observation as a post-remission choice in the survival of adult patients with peripheral T-cell lymphoma: Post hoc analysis of a prospective, multicenter, phase 2 study in China
In this prospective, multicenter, Phase 2 clinical trial (NCT02987244), patients with peripheral T-cell lymphomas (PTCLs) who had responded to first-line chemotherapy with cyclophosphamide, doxorubicin or epir...
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Article
Correction to: Potential therapeutic role of punicalagin against mechanical-trauma-induced stress urinary incontinence via upregulation of Nrf2 and TGF-β1 signaling
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Article
Characteristics and literature review of ETV6::ABL1 fusion gene-positive acute myeloid leukemia
To describe the features of ETV6::ABL1 AML as well as the clinical treatment and outcomes.
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Article
Efficient numerical-simulation-based slope reliability analysis considering spatial variability
Currently, numerical-simulation-based slope reliability analysis (NSB-SRA) considering spatial variability is still a time-consuming task. To address this problem, this study proposed an efficient numerical-si...
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Article
Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance
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Article
Comparison of Machine Learning Models Using Diffusion-Weighted Images for Pathological Grade of Intrahepatic Mass-Forming Cholangiocarcinoma
Is the radiomic approach, utilizing diffusion-weighted imaging (DWI), capable of predicting the various pathological grades of intrahepatic mass-forming cholangiocarcinoma (IMCC)? Furthermore, which model demo...
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Article
Humanoid robot action using multi-mode fusion based on frame expert system
This research combines the NAO robot platform to develop three single scene modes (visual line-following navigation, object location and grabbing, and moving object tracking and obstacle avoidance), and finall...
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Article
Open AccessAn investigation into the present status and influencing factors of nurse retention in grade-a tertiary general hospitals in Shanxi Province within the framework of the magnet hospital concept
The attrition of nursing staff significantly contributes to the shortage of healthcare professionals. This study entailed an examination of the propensity of nurses to sustain employment within Grade-A tertiar...
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Article
Gene–gene interaction network analysis indicates CNTN2 is a candidate gene for idiopathic generalized epilepsy
Twin and family studies have established the genetic contribution to idiopathic generalized epilepsy (IGE). The genetic architecture of IGE is generally complex and heterogeneous, and the majority of the genet...
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Article
A study on double-cantilever miniaturized FBG acceleration sensors for low-frequency vibration monitoring
The measurement of low-frequency vibration signals is of great significance for the studies on the seismic monitoring of railway transportation, bridges, and civil building structures. Aiming at the problem th...
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Article
Bond behavior of the interface between concrete and basalt fiber reinforced polymer bar after freeze-thaw cycles
The shear bond of interface between concrete and basalt fiber reinforced polymer (BFRP) bars during freeze-thaw (F-T) cycles is crucial for the application of BFRP bar-reinforced concrete structures in cold re...
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Article
Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis
As a vital component of the hepatitis B virus (HBV) nucleocapsid, HBV core protein (HBC) contributes to hepatocarcinogenesis. Here, we aimed to assess the effects of RANGAP1 and KDM2A on tumorigenesis induced ...
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Article
Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis
Osteoporosis results from overactivation of osteoclasts. There are currently few drug options for treatment of this disease. Since the successful development of allosteric inhibitors, phosphatases have become ...
