141 Result(s)
within
Li-**n He
Biochemistry, general
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Article
Metabolome and Genome Analysis of a Novel Endophytic Fungus Aureobasidium pullulans KB3: Discovery of Polyketones and Polyketone Biosynthesis Pathway
Endophytic fungi associated with plants may contain undiscovered bioactive compounds. Under standard laboratory conditions, most undiscovered compounds are inactive, whereas their production could be stimulate...
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Article
Open AccessDysregulated dendritic cells in sepsis: functional impairment and regulated cell death
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Studies have indicated that immune dysfunction plays a central role in the pathogenesis of sepsis. D...
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Article
Isolation, identification, and tolerance analysis of yeast during the natural fermentation process of Sidamo coffee beans
Yeast, which plays a pivotal role in the brewing, food, and medical industries, exhibits a close relationship with human beings. In this study, we isolated and purified 60 yeast strains from the natural fermen...
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Article
Open AccessNLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis
Members of the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing (NLRP) family regulate various physiological and pathological processes. However, none have been shown ...
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Article
The Osmolality and Hemolysis of High-Concentration Monoclonal Antibody Formulations
Highly concentrated monoclonal antibody (mAb) formulations for subcutaneous administration are becoming increasingly preferred within the biopharmaceutical industry for ease of use and improved patient complia...
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Article
Open AccessAPC mutations disrupt β-catenin destruction complex condensates organized by Axin phase separation
The Wnt/β-catenin pathway is critical to maintaining cell fate decisions. Recent study showed that liquid–liquid-phase separation (LLPS) of Axin organized the β-catenin destruction complex condensates in a nor...
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Article
Boron-enabled 1,3-metallate shift towards axially chiral alkenes
Tetracoordinate boron molecules are the key intermediates in many organoboron-related chemical transformations. Now, using alkynyl tetracoordinate boron species, a nickel-catalysed asymmetric 1,3-metallate shi...
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Article
Triptolide induces PANoptosis in macrophages and causes organ injury in mice
Macrophages represent the first lines of innate defense against pathogenic infections and are poised to undergo multiple forms of regulated cell death (RCD) upon infections or toxic stimuli, leading to multipl...
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Article
Open AccessDNA methylation-activated full-length EMX1 facilitates metastasis through EMX1-EGFR-ERK axis in hepatocellular carcinoma
Altered DNA methylation is a crucial epigenetic event in hepatocellular carcinoma (HCC) development and progression. Through methylation-transcriptomic analysis, we identified a set of sixty potential DNA meth...
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Article
Open AccessCorrection: ACE2 deficiency exacerbates obesity-related glomerulopathy through its role in regulating lipid metabolism
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Article
Citrus medica var. Sarcodactylus (Siebold ex Hoola van Nooten) Swingle: an insight into its botany, traditional uses, phytochemistry, and pharmacological properties
Citrus medica var. sarcodactylus (Siebold ex Hoola van Nooten) Swingle is not only a delicious fruit with rich nutrients, but also a traditional Chinese medicine with clinical values. The botanical characteristic...
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Article
Phytochemistry, data mining, pharmacology, toxicology and the analytical methods of Cyperus rotundus L. (Cyperaceae): a comprehensive review
Cyperus rotundus L. has been widely used in the treatment and prevention of numerous diseases in traditional systems of medicine around the world, such as nervous, gastrointestinal systems diseases and inflammati...
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Article
Open AccessThe deubiquitinase Leon/USP5 interacts with Atg1/ULK1 and antagonizes autophagy
Accumulating evidence has shown that the quality of proteins must be tightly monitored and controlled to maintain cellular proteostasis. Misfolded proteins and protein aggregates are targeted for degradation t...
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Article
Baicalein sensitizes triple negative breast cancer MDA-MB-231 cells to doxorubicin via autophagy-mediated down-regulation of CDK1
Triple negative breast cancer (TNBC) is a kind of refractory cancer with poor response to conventional chemotherapy. Recently, the combination of baicalein and doxorubicin was reported to exert a synergistic a...
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Article
A novel neodymium-mercury material with red photoluminescence: synthesis, characterization, photophysical properties and energy transfer mechanism
A novel neodymium-mercury material with a two-dimensional (2-D) layer-like structure, namely [Nd(HIA)2(H2O)2Hg2Cl5(IA)]nn(HgCl2)·5nH2O·nCl (marked as 1; HIA means isonicotinic acid), has been successfully synthes...
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Article
Open AccessAberrant RNA m6A modification in gastrointestinal malignancies: versatile regulators of cancer hallmarks and novel therapeutic opportunities
Gastrointestinal (GI) cancer is one of the most common malignancies, and a leading cause of cancer-related death worldwide. However, molecular targeted therapies are still lacking, leading to poor treatment ef...
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Article
Open AccessTargeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma
Anillin (ANLN) is a mitosis-related protein that promotes contractile ring formation and cytokinesis, but its cell cycle-dependent degradation mechanisms in cancer cells remain unclear. Here, we show that high...
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Article
Open AccessTPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs
The pregnane X receptor (PXR) is an important regulator of hepatocellular carcinoma cellular resistance to antitumor drugs. Activation of PXR was modulated by the co-regulators. The target protein for the Xeno...
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Article
Open AccessRetraction Note: MicroRNA-221-3p, a TWIST2 target, promotes cervical cancer metastasis by directly targeting THBS2
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Article
Open AccessScaling-up and proteomic analysis reveals photosynthetic and metabolic insights toward prolonged H2 photoproduction in Chlamydomonas hpm91 mutant lacking proton gradient regulation 5 (PGR5)
Clean and sustainable H2 production is crucial to a carbon–neutral world. H2 generation by Chlamydomonas reinhardtii is an attractive approach for solar-H2 from H2O. However, it is currently not large-scalable be...
