258 Result(s)
within
English
Life Sciences
Biochemistry, general
Immunology
Li**g Du
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Chapter and Conference Paper
Simulation Study of Breast Tissue Hemodynamics During Pressure Perturbation
We simulated the effects of compression of the breast on blood volume and tissue oxygenation. We sought to answer the question: how does the compression during breast examination impact on the circulatory syst...
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Article
Open AccessThe antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress
Falcarindiol (FAD) is a natural polyyne with various beneficial biological activities. We show here that FAD preferentially kills colon cancer cells but not normal colon epithelial cells. Furthermore, FAD inhi...
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Article
Open AccessEffect of FK506 in reducing scar formation by inducing fibroblast apoptosis after sciatic nerve injury in rats
We previously demonstrated that FK506, a generally applied immunosuppressant in organ transplantation, could promote peripheral nerve regeneration through reducing scar formation. However, little is known abou...
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Article
Open AccessGlycation exacerbates the neuronal toxicity of β-amyloid
Accumulation evidence shows that β-amyloid (Aβ) is a neurotoxic and accumulation of Aβ is responsible for the pathology of Alzheimer’s disease (AD). However, it is currently not fully understood what makes Aβ tox...
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Article
Open AccessThe JAK2/STAT3 and mitochondrial pathways are essential for quercetin nanoliposome-induced C6 glioma cell death
The formulation of quercetin nanoliposomes (QUE-NLs) has been shown to enhance QUE antitumor activity in C6 glioma cells. At high concentrations, QUE-NLs induce necrotic cell death. In this study, we probed th...
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Article
Decreased Na+/K+ ATPase α1 (ATP1A1) gene expression in major depression patients’ peripheral blood
Major depression affects the central nervous system and thereafter the autonomic nervous system, immune system, and endocrine system. Na+/K+ ATPase, as a major mediator of cellular transmembrane ionic gradient...
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Article
Open AccessCalcineurin suppresses AMPK-dependent cytoprotective autophagy in cardiomyocytes under oxidative stress
Calcineurin signalling plays a critical role in the pathogenesis of many cardiovascular diseases. Calcineurin has been proven to affect a series of signalling pathways and to exert a proapoptotic effect in car...
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Article
Open AccessKnockdown of BAG3 induces epithelial–mesenchymal transition in thyroid cancer cells through ZEB1 activation
The process by which epithelial features are lost in favor of a mesenchymal phenotype is referred to as epithelial–mesenchymal transition (EMT). Most carcinomas use this mechanism to evade into neighboring tis...
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Article
Open AccessThe aPKCι blocking agent ATM negatively regulates EMT and invasion of hepatocellular carcinoma
Epithelial-to-mesenchymal transition (EMT) has an important role in invasion and metastasis of hepatocellular carcinoma (HCC). To explore the regulatory mechanism of atypical protein kinase C ι (aPKCι) signaling ...
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Article
Open AccessURI regulates tumorigenicity and chemotherapeutic resistance of multiple myeloma by modulating IL-6 transcription
Unconventional prefoldin RPB5 interactor (URI), which acts as an oncoprotein in solid tumors, is associated with RNA polymerase II subunit 5. However, its impact on multiple myeloma (MM) has not been determine...
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Article
Open AccessThe histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice
Self-renewal and differentiation of spermatogonial stem cells (SSCs) are the foundation of spermatogenesis throughout a male’s life. SSC transplantation will be a valuable solution for young male patients to p...
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Article
Open AccessAnticancer compound Oplopantriol A kills cancer cells through inducing ER stress and BH3 proteins Bim and Noxa
Oplopantriol-A (OPT) is a natural polyyne from Oplopanax horridus. We show here that OPT preferentially kills cancer cells and inhibits tumor growth. We demonstrate that OPT-induced cancer cell death is mediated ...
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Article
Open AccessSulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling
The present study was designed to investigate the role of endogenous sulfur dioxide (SO2) in vascular smooth muscle cell (VSMC) proliferation, and explore the possible role of cross-talk between cyclic adenosine ...
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Article
Open AccessMitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model
Diabetic neuropathy develops on a background of hyperglycemia and an entangled metabolic imbalance. There is increasing evidence of central nervous system involvement in diabetic neuropathy and no satisfactory...
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Article
Open AccessGenetic deficiency of neuronal RAGE protects against AGE-induced synaptic injury
Synaptic dysfunction and degeneration is an early pathological feature of aging and age-related diseases, including Alzheimer’s disease (AD). Aging is associated with increased generation and deposition of adv...
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Article
Open AccessmiR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7
Here we show that transgenic expression of miR-17 extends lifespan and inhibits cellular senescence. We propose that miR-17 acts as a critical regulator of cellular senescence and tumorigenesis. We demonstrate...
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Article
Open AccessSmall molecules, big effects: the role of microRNAs in regulation of cardiomyocyte death
MicroRNAs (miRNAs) are a class of small non-coding RNAs involved in posttranscriptional regulation of gene expression, and exerting regulatory roles in plethora of biological processes. In recent years, miRNAs...
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Article
Open AccessMicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy
Diabetic cardiomyopathy is a common cardiac condition in patients with diabetes mellitus, which can result in cardiac hypertrophy and subsequent heart failure, associated with pyroptosis, the pro-inflammatory ...
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Article
Open AccessMicroRNA-207 enhances radiation-induced apoptosis by directly targeting akt3 in cochlea hair cells
MicroRNAs (miRNAs) have important roles in various types of cellular biological processes. Our study aimed to determine whether miRNAs function in the regulation of ionizing radiation (IR)-induced cell death i...
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Article
Open AccessThe activation of G protein-coupled receptor 30 (GPR30) inhibits proliferation of estrogen receptor-negative breast cancer cells in vitro and in vivo
There is an urgent clinical need for safe and effective treatment agents and therapy targets for estrogen receptor negative (ER−) breast cancer. G protein-coupled receptor 30 (GPR30), which mediates non-genomi...
