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  1. Article

    Open Access

    Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade

    Rheumatoid arthritis (RA) is a chronic disease associated with inflammation and destruction of bone and cartilage. Although inhibition of TNFα is widely used to treat RA, a significant number of patients do no...

    Luke L Gompels, Nasser M Malik, Leigh Madden, Pei **… in Arthritis Research & Therapy (2011)

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  2. Article

    Open Access

    Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis

    Rheumatoid arthritis (RA) is characterised by invasion of cartilage, bone and tendon by inflamed synovium. Previous studies in our laboratory have shown that hypoxia is a feature of RA synovitis. In the presen...

    Mohammed A Akhavani, Leigh Madden, Ian Buysschaert… in Arthritis Research & Therapy (2009)

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  3. Article

    Open Access

    Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition

    The enzyme methionine aminopeptidase-2 (MetAP-2) is thought to play an important function in human endothelial cell proliferation, and as such provides a valuable target in both inflammation and cancer. Rheuma...

    John Bainbridge, Leigh Madden, David Essex, Michael Binks… in Arthritis Research & Therapy (2007)

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