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  1. Article

    Open Access

    Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation

    Protein SUMOylation provides a principal driving force for cellular stress responses, including DNA–protein crosslink (DPC) repair and arsenic-induced PML body degradation. In this study, using genome-scale sc...

    Julio C. Y. Liu, Leena Ackermann, Saskia Hoffmann… in Nature Structural & Molecular Biology (2024)

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  2. Article

    E4 ligase–specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis

    The E4 ligase UFD-2 is required for apoptosis induced by DNA damage in C. elegans, and for the resolution of RAD-51 foci during homologous recombination-dependent repair, thus coordinating these two cellular proc...

    Leena Ackermann, Michael Schell, Wojciech Pokrzywa… in Nature Structural & Molecular Biology (2016)

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    Article

    The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

    The E3 ubiquitin ligases RNF8 and RNF168 are required for recruitment of tumor surpressor 53BP1 to sites of DNA double-strand breaks. The reasons for this have been unclear, as 53BP1 recognizes histone mark H4...

    Klara Acs, Martijn S Luijsterburg, Leena Ackermann… in Nature Structural & Molecular Biology (2011)