4 Result(s)
within
Leanne Jade G. Chan
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessA microbial supply chain for production of the anti-cancer drug vinblastine
Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinblastine and vincristine1. As MI...
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Article
Open AccessIndustrial brewing yeast engineered for the production of primary flavor determinants in hopped beer
Flowers of the hop plant provide both bitterness and “hoppy” flavor to beer. Hops are, however, both a water and energy intensive crop and vary considerably in essential oil content, making it challenging to a...
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Article
Open AccessProgramming mRNA decay to modulate synthetic circuit resource allocation
Synthetic circuits embedded in host cells compete with cellular processes for limited intracellular resources. Here we show how funnelling of cellular resources, after global transcriptome degradation by the s...
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Article
Open AccessMetabolic engineering for the high-yield production of isoprenoid-based C5 alcohols in E. coli
Branched five carbon (C5) alcohols are attractive targets for microbial production due to their desirable fuel properties and importance as platform chemicals. In this study, we engineered a heterologous isopreno...
