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  1. Article

    Open Access

    Mottling as a prognosis marker in cardiogenic shock

    Impact of skin mottling has been poorly studied in patients admitted for cardiogenic shock. This study aimed to address this issue and identify determinants of 30-day and 1-year mortality in a large cardiogeni...

    Hamid Merdji, Vincent Bataille, Anais Curtiaud, Laurent Bonello… in Annals of Intensive Care (2023)

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    Article

    Uric acid levels are associated with endothelial dysfunction and severity of coronary atherosclerosis during a first episode of acute coronary syndrome

    The role of serum uric acid in coronary artery disease has been extensively investigated. It was suggested that serum uric acid level (SUA) is an independent predictor of endothelial dysfunction and related to...

    Mélanie Gaubert, Marion Marlinge, Marine Alessandrini, Marc Laine… in Purinergic Signalling (2018)

  3. No Access

    Article

    Controlled sedation with midazolam and analgesia with nalbuphine to alleviate pain in patients undergoing subcutaneous implantable cardioverter defibrillator implantation

    Subcutaneous implantable cardioverter defibrillator (S-ICD) is an alternative to transvenous ICD to prevent sudden cardiac death. Subcutaneous ICD implantation frequently requires general anesthesia because of...

    Michaël Peyrol, Jérémie Barraud… in Journal of Interventional Cardiac Electrop… (2017)

  4. Article

    Open Access

    Spare Adenosine A2a Receptors Are Associated with Positive Exercise Stress Test in Coronary Artery Disease

    During exercise, cardiac oxygen consumption increases and the resulting low oxygen level in the myocardium triggers coronary vasodilation. This response to hypoxia is controlled notably by the vasodilator aden...

    Jean Ruf, Franck Paganelli, Laurent Bonello, Nathalie Kipson… in Molecular Medicine (2016)

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  5. No Access

    Article

    Clopidogrel Response Variability: Etiology and Clinical Relevance

    Antiplatelet therapy is key to the care of coronary artery disease. Continuous improvement in the understanding of athero-thrombosis and the pathways of platelet activation has led to tremendous enhancement in...

    Laurent Bonello, Mélanie Gaubert, Marc Laine… in Current Cardiovascular Risk Reports (2015)

  6. No Access

    Article

    Clinical Impact of Genetically Determined Platelet Reactivity

    Dual antiplatelet therapy with aspirin and clopidogrel dramatically reduced the rate of major adverse cardiac events following percutaneous coronary intervention. Clopidogrel is a prodrug which requires a two-...

    Marc Laine, Sébastien Arméro, Michaël Peyrol… in Journal of Cardiovascular Translational Re… (2013)

  7. No Access

    Article

    Genotypic and Phenotypic Assessment of Platelet Function and Response to P2Y12 Antagonists

    The P2Y12-ADP receptor antagonists are the cornerstone of oral antiplatelet therapy in the secondary prevention of coronary artery disease, especially after acute coronary syndrome or percutaneous coronary int...

    Axel de Labriolle, Jean Philippe Doazan, Gilles Lemesle… in Current Cardiology Reports (2011)

  8. No Access

    Article

    Personalized Antiplatelet Therapy: Review of the Latest Clinical Evidence

    P2Y12-ADP receptor antagonist use has been critical in the development of percutaneous coronary intervention, dramatically reducing the rate of early stent thrombosis. However, it recently was observed that a ...

    Elise Camilleri, Laurent Jacquin, Franck Paganelli… in Current Cardiology Reports (2011)