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The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17

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  1. Article

    Open Access

    Neural deficits in a mouse model of PACS1 syndrome are corrected with PACS1- or HDAC6-targeting therapy

    PACS1 syndrome is a neurodevelopmental disorder (NDD) caused by a recurrent de novo missense mutation in PACS1 (p.Arg203Trp (PACS1R203W)). The mechanism by which PACS1R203W causes PACS1 syndrome is unknown, and n...

    Sabrina Villar-Pazos, Laurel Thomas, Yunhan Yang, Kun Chen… in Nature Communications (2023)

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  2. Article

    Open Access

    Rab32 uses its effector reticulon 3L to trigger autophagic degradation of mitochondria-associated membrane (MAM) proteins

    Rab32 is a small GTPase associated with multiple organelles but is particularly enriched at the endoplasmic reticulum (ER). Here, it controls targeting to mitochondria-ER contacts (MERCs), thus influencing com...

    Maria Sol Herrera-Cruz, Megan C. Yap, Nasser Tahbaz, Keelie Phillips… in Biology Direct (2021)

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    Open Access

    Oral perfluorooctane sulfonate (PFOS) lessens tumor development in the APCmin mouse model of spontaneous familial adenomatous polyposis

    Colorectal cancer is the second most common cause of cancer deaths for both men and women, and the third most common cause of cancer in the U.S. Toxicity of current chemotherapeutic agents for colorectal cance...

    Jeffrey Wimsatt, Meghan Villers, Laurel Thomas, Stacey Kamarec… in BMC Cancer (2016)

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  4. Article

    Open Access

    Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen

    HIV-1 Nef is a viral accessory protein critical for AIDS progression. Nef lacks intrinsic catalytic activity and binds multiple host cell signaling proteins, including Hck and other Src-family tyrosine kinases...

    Ronald P Trible, Purushottam Narute, Lori A Emert-Sedlak… in Retrovirology (2013)

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