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  1. Article

    Open Access

    Neural deficits in a mouse model of PACS1 syndrome are corrected with PACS1- or HDAC6-targeting therapy

    PACS1 syndrome is a neurodevelopmental disorder (NDD) caused by a recurrent de novo missense mutation in PACS1 (p.Arg203Trp (PACS1R203W)). The mechanism by which PACS1R203W causes PACS1 syndrome is unknown, and n...

    Sabrina Villar-Pazos, Laurel Thomas, Yunhan Yang, Kun Chen… in Nature Communications (2023)

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  2. No Access

    Article

    The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17

    The metalloproteinase ADAM17 activates ErbB signalling by releasing ligands from the cell surface, a key step underlying epithelial development, growth and tumour progression. However, mechanisms acutely contr...

    Sarah Louise Dombernowsky, Jacob Samsøe-Petersen… in Nature Communications (2015)