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Open AccessDisease burden of stroke and its subtypes attributable to low dietary fiber in China, 1990–2019
This study aimed to assess the current status and changing trends of the disease burden of stroke and its subtypes due to low dietary fiber intake in China from 1990 to 2019. In cases of stroke and its subtype...
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Open AccessExploring the pathways of drug repurposing and Panax ginseng treatment mechanisms in chronic heart failure: a disease module analysis perspective
Chronic Heart Failure (CHF) is a significant global public health issue, with high mortality and morbidity rates and associated costs. Disease modules, which are collections of disease-related genes, offer an ...
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Article
Open AccessBioinformatics analysis and experimental verification of the cancer-promoting effect of DHODH in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is a malignant tumor of the urinary system. To explore the potential mechanisms of DHODH in ccRCC, we analyzed its molecular characteristics using public databases. TCGA...
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Open AccessInvestigation of temperature effects on wide steel box girder of suspension bridge based on long-term monitoring data
The time-varying temperature distributions on bridge structures may remarkably change structural performance, which may result in differential strain/stress responses on structural members compared with the de...
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Open AccessAcute interval running induces greater excess post-exercise oxygen consumption and lipid oxidation than isocaloric continuous running in men with obesity
Studies seem to show that high-intensity interval training (HIIT) is a more time-efficient protocol for weight loss, compared with moderate-intensity continuous training (MICT). Our aim was to compare the acut...
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Open AccessHighly robust supramolecular polymer networks crosslinked by a tiny amount of metallacycles
Supramolecular polymeric materials have exhibited attractive features such as self-healing, reversibility, and stimuli-responsiveness. However, on account of the weak bonding nature of most noncovalent interac...
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Open AccessGenome-wide epistasis analysis reveals gene–gene interaction network on an intermediate endophenotype P-tau/Aβ42 ratio in ADNI cohort
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the elderly worldwide. The exact etiology of AD, particularly its genetic mechanisms, remains incom...
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Open AccessStrain-restricted transfer of ferromagnetic electrodes for constructing reproducibly superior-quality spintronic devices
Spintronic device is the fundamental platform for spin-related academic and practical studies. However, conventional techniques with energetic deposition or boorish transfer of ferromagnetic metal inevitably i...
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Open AccessIntegrated global assessment of the natural forest carbon potential
Forests are a substantial terrestrial carbon sink, but anthropogenic changes in land use and climate have considerably reduced the scale of this system1. Remote-sensing estimates to quantify carbon losses from gl...
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Open AccessA Notch signaling-related lncRNA signature for predicting prognosis and therapeutic response in clear cell renal cell carcinoma
Increasing evidence has confirmed the vital role of Notch signaling in the tumorigenesis of clear cell renal cell carcinoma (ccRCC). The underlying function of long non-coding RNA (lncRNA) related to Notch sig...
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Open AccessAll electromagnetic scattering bodies are matrix-valued oscillators
Scattering theory is the basis of all linear optical and photonic devices, whose spectral response underpins wide-ranging applications from sensing to energy conversion. Unlike the Shannon theory for communica...
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Open AccessMutation of key signaling regulators of cerebrovascular development in vein of Galen malformations
To elucidate the pathogenesis of vein of Galen malformations (VOGMs), the most common and most severe of congenital brain arteriovenous malformations, we performed an integrated analysis of 310 VOGM proband-fa...
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Open AccessUnveiling the dynamic active site of defective carbon-based electrocatalysts for hydrogen peroxide production
Active sites identification in metal-free carbon materials is crucial for develo** practical electrocatalysts, but resolving precise configuration of active site remains a challenge because of the elusive dy...
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Open AccessDefining the condensate landscape of fusion oncoproteins
Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing liquid-liquid phase separation (LLPS)...
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Article
Precessing jet nozzle connecting to a spinning black hole in M87
The nearby radio galaxy M87 offers a unique opportunity to explore the connections between the central supermassive black hole and relativistic jets. Previous studies of the inner region of M87 revealed a wide...
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Open AccessNative diversity buffers against severity of non-native tree invasions
Determining the drivers of non-native plant invasions is critical for managing native ecosystems and limiting the spread of invasive species1,2. Tree invasions in particular have been relatively overlooked, even ...
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Open AccessAn innovative ensemble model based on deep learning for predicting COVID-19 infection
Nowadays, global public health crises are occurring more frequently, and accurate prediction of these diseases can reduce the burden on the healthcare system. Taking COVID-19 as an example, accurate prediction...
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Open AccessAnomalous polarization enhancement in a van der Waals ferroelectric material under pressure
CuInP2S6 with robust room-temperature ferroelectricity has recently attracted much attention due to the spatial instability of its Cu cations and the van der Waals (vdW) layered structure. Herein, we report a sig...
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Open AccessA 13-million turnover-number anionic Ir-catalyst for a selective industrial route to chiral nicotine
Develo** catalysts with both useful enantioselectivities and million turnover numbers (TONs) for asymmetric hydrogenation of ketones is attractive for industrial production of high-value bioactive chiral ent...
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Improving interface quality for 1-cm2 all-perovskite tandem solar cells
All-perovskite tandem solar cells provide high power conversion efficiency at a low cost1–4. Rapid efficiency improvement in small-area (<0.1 cm2) tandem solar cells has been primarily driven by advances in low-b...