22 Result(s)
within
LIN TANG
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessCortex-wide transcranial localization microscopy with fluorescently labeled red blood cells
Large-scale imaging of brain activity with high spatio-temporal resolution is crucial for advancing our understanding of brain function. The existing neuroimaging techniques are largely limited by restricted f...
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Article
Open AccessTwistedly hydrophobic basis with suitable aromatic metrics in covalent organic networks govern micropollutant decontamination
The pre-designable structure and unique architectures of covalent organic frameworks (COFs) render them attractive as active and porous medium for water crisis. However, the effect of functional basis with dif...
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Article
Open AccessDual donor-acceptor covalent organic frameworks for hydrogen peroxide photosynthesis
Constructing photocatalytically active and stable covalent organic frameworks containing both oxidative and reductive reaction centers remain a challenge. In this study, benzotrithiophene-based covalent organi...
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Article
Open AccessRituximab treatment of adults with primary focal segmental glomerulosclerosis
To evaluate the efficacy and safety of rituximab (RTX) in the treatment of primary focal segmental glomerulosclerosis (FSGS) in adults. The clinical data of patients with primary FSGS who received RTX treatmen...
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Article
Open AccessArtificial intelligence reveals dysregulation of osteosarcoma and cuproptosis-related biomarkers, PDHA1, CDKN2A and neutrophils
At present, the impact of cuproptosis-related genes in the study of osteosarcoma is largely unknown. Genome-wide data of osteosarcoma and controls were downloaded from 3 different databases, and specific diagn...
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Article
Open AccessHigh-throughput primer design by scoring in piecewise logistic model for multiple polymerase chain reaction variants
Polymerase chain reaction (PCR) variants requiring specific primer types are widely used in various PCR experiments, including generic PCR, inverse PCR, anchored PCR, and ARMS PCR. Few tools can be adapted for...
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Article
Open AccessHeterogeneous graph neural network for lncRNA-disease association prediction
Identifying lncRNA-disease associations is conducive to the diagnosis, treatment and prevention of diseases. Due to the expensive and time-consuming methods verified by biological experiments, prediction metho...
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Open AccessClinicopathological characteristics and prognosis of hepatitis B associated membranous nephropathy and idiopathic membranous nephropathy complicated with hepatitis B virus infection
The main objective of this study is to analyze the clinical and pathological features and prognosis of patients with Hepatitis B associated membranous nephropathy (HBV-MN) and idiopathic membranous nephropathy...
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Open AccessClinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study
The objective of the study was to evaluate the clinicopathological characteristics and investigate the clinical determinants of patient and renal survival in the first 12 months after diagnosis in anti-neutrop...
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Article
Open AccessUpconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy
NIR-II fluorophores have shown great promise for biomedical applications with superior in vivo optical properties. To date, few small-molecule NIR-II fluorophores have been discovered with donor-acceptor-donor...
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Article
Open AccessImmobilization of cadmium and lead in contaminated paddy field using inorganic and organic additives
Heavy metal contamination of agricultural soils has posed a risk to environment and human health. The present study was conducted to assess the effectiveness of soil amendments for reducing cadmium (Cd) and le...
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Article
Open AccessCorrection: Corrigendum: PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer
Scientific Reports 7: Article number: 42319; published online: 08 February 2017; updated: 16 March 2017 This Article contains an error in Figure 4A where the graphs were labelled incorrectly. The correct Figur...
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Article
Open AccessSimultaneous removal of atrazine and copper using polyacrylic acid-functionalized magnetic ordered mesoporous carbon from water: adsorption mechanism
Highly efficient simultaneous removal of atrazine and Cu(II) was accomplished using synthesized polyacrylic acid-functionalized magnetic ordered mesoporous carbon (P-MMC) as compared to magnetic ordered mesopo...
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Article
Open AccessPARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer
Emerging evidence has shown that adding poly(ADP-ribose) polymerase (PARP) inhibitors to chemotherapy regimens is superior to the control regimens alone in BRCA1-mutated triple-negative breast cancer (TNBC) pa...
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Article
Open AccessAn overview of topic modeling and its current applications in bioinformatics
With the rapid accumulation of biological datasets, machine learning methods designed to automate data analysis are urgently needed. In recent years, so-called topic models that originated from the field of na...
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Article
Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs
Calcium channel blockers are widely used to treat cardiovascular diseases; new structural studies uncover how two different types of calcium-channel blockers bind to the channel; the drugs bind in different lo...
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Article
Structural basis for Ca2+ selectivity of a voltage-gated calcium channel
Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. How CaV channels solve this fundamental biophysical pro...
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Article
Open AccessEvolution of the human-specific microRNA miR-941
MicroRNA-mediated gene regulation is important in many physiological processes. Here we explore the roles of a microRNA, miR-941, in human evolution. We find that miR-941 emerged de novo in the human lineage, bet...
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Article
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel
The crystal structure of NavRh, a NaChBac orthologue from the marine Rickettsiales sp. HIMB114, defines an ion binding site within the selectivity filter, and reveals several conformational rearrangements that ma...
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Article
Preparation, characterization and preliminary in vivo studies of inactivated SARS-CoV vaccine
A large quantity of SARS-CoV virus was proliferated in Vero cells, inactivated with β-propiolactone, then purified by Sepharose 4FF column chromatography to prepare inactivated vaccine. The vaccine was identif...
