117 Result(s)

Article

Insight into the mechanism of action of ORG27569 at the cannabinoid type one receptor utilising a unified mathematical model

Allosteric modulation of CB₁ is therapeutically advantageous compared to orthosteric activation as it potentially offers reduced on-target adverse effects. ORG27569 is an allosteric modulator that increases ortho...

Hayley M. Green, Liang Yang, **ao Zhu… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2024)

Article

Embosphere microspheres size for bronchial artery embolization in patients with hemoptysis caused by bronchiectasis: a retrospective comparative analysis of 500–750 versus 700–900 μm microspheres

Bronchial arterial embolization (BAE) has been accepted as an effective treatment for bronchiectasis-related hemoptysis. However, rare clinical trials compare different sizes of specific embolic agents. This s...

Hong-Dou Xu, Liang Yang, Shi-Bing Hu in BMC Pulmonary Medicine (2024)

Article

Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing

Chronic wounds are often infected with biofilm bacteria and characterized by high oxidative stress. Current dressings that promote chronic wound healing either require additional processes such as photothermal...

Dicky Pranantyo, Chun Kiat Yeo, Yang Wu, Chen Fan, **aofei Xu… in Nature Communications (2024)

Article

An access control model based on blockchain master-sidechain collaboration

The centralized storage and centralized authorization approach in medical information systems can lead to data tampering and private information privacy leakage, while the traditional access control model has ...

Liang Yang, Rong Jiang, Xuetao Pu, Chenguang Wang, Yue Yang, Meng Wang… in Cluster Computing (2024)

Article

NAD⁺ dependent UPR^mt activation underlies intestinal aging caused by mitochondrial DNA mutations

Aging in mammals is accompanied by an imbalance of intestinal homeostasis and accumulation of mitochondrial DNA (mtDNA) mutations. However, little is known about how accumulated mtDNA mutations modulate intest...

Liang Yang, Zifeng Ruan, **aobing Lin, Hao Wang, Yanmin **n… in Nature Communications (2024)

Article

Phase separation as a possible mechanism for dosage sensitivity

Deletion of haploinsufficient genes or duplication of triplosensitive ones results in phenotypic effects in a concentration-dependent manner, and the mechanisms underlying these dosage-sensitive effects remain...

Liang Yang, Jiali Lyu, ** Li, Gaigai Guo, Xueya Zhou, Taoyu Chen, Yi Lin… in Genome Biology (2024)

Article

Melatonin attenuates diabetic cardiomyopathy by increasing autophagy of cardiomyocytes via regulation of VEGF-B/GRP78/PERK signaling pathway

Diabetic cardiomyopathy (DCM) is a major cause of mortality in patients with diabetes, and the potential strategies for treating DCM are insufficient. Melatonin (Mel) has been shown to attenuate DCM, however, ...

Shengzheng Zhang, Wencong Tian, **anxian Duan, Qian Zhang… in Cardiovascular Diabetology (2024)

Article

Glutamine addiction in tumor cell: oncogene regulation and clinical treatment

 After undergoing metabolic reprogramming, tumor cells consume additional glutamine to produce amino acids, nucleotides, fatty acids, and other substances to facilitate their unlimited proliferation. As such, ...

**an Li, Xueqiang Peng, Yan Li, Shibo Wei, Guangpeng He… in Cell Communication and Signaling (2024)

Article

Optogenetic induction of caspase-8 mediated apoptosis by employing Arabidopsis cryptochrome 2

Apoptosis, a programmed cell death mechanism, is a regulatory process controlling cell proliferation as cells undergo demise. Caspase-8 serves as a pivotal apoptosis-inducing factor that initiates the death re...

Weiliang Mo, Shengzhong Su, Ruige Shang, Liang Yang, Xuelai Zhao… in Scientific Reports (2023)

Article

Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma

Emerging evidence indicates that SOX2 is an oncogene for esophageal squamous cell carcinoma (ESCC). However, direct targeting of SOX2 is not feasible given that this transcription factor plays important roles ...

Yunyun Chen, Kun Zhang, Rui Zhang, Zhuo Wang, Liang Yang… in Cell Death Discovery (2023)

Article

Efficient plant genome engineering using a probiotic sourced CRISPR-Cas9 system

Among CRISPR-Cas genome editing systems, Streptococcus pyogenes Cas9 (SpCas9), sourced from a human pathogen, is the most widely used. Here, through in silico data mining, we have established an efficient plant g...

Zhaohui Zhong, Guanqing Liu, Zhongjie Tang, … in Nature Communications (2023)

Article

Extracellular vesicle-cell adhesion molecules in tumours: biofunctions and clinical applications

Cell adhesion molecule (CAM) is an umbrella term for several families of molecules, including the cadherin family, integrin family, selectin family, immunoglobulin superfamily, and some currently unclassified ...

Weikai Lin, Jianjun Fang, Shibo Wei, Guangpeng He… in Cell Communication and Signaling (2023)

Article

The diversified role of mitochondria in ferroptosis in cancer

Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation, and it has been studied extensively since its discovery in 2012. Induced by iron overload and ROS accumulation, ferro...

Yu’e Liu, Shi** Lu, Lei-lei Wu, Liang Yang, Lixue Yang… in Cell Death & Disease (2023)

Article

Light-triggered multi-joint microactuator fabricated by two-in-one femtosecond laser writing

Inspired by the flexible joints of humans, actuators containing soft joints have been developed for various applications, including soft grippers, artificial muscles, and wearable devices. However, integrating...

Chen **n, Zhongguo Ren, Leran Zhang, Liang Yang, Dawei Wang… in Nature Communications (2023)

Article

Crosstalk between autophagy and CSCs: molecular mechanisms and translational implications

Cancer stem cells(CSCs) play a key role in regulating tumorigenesis, progression, as well as recurrence, and possess typical metabolic characteristics. Autophagy is a catabolic process that can aid cells to su...

Dai Li, Xueqiang Peng, Guangpeng He, Jiaxing Liu, **an Li… in Cell Death & Disease (2023)

Article

Vitamin D promotes epithelial tissue repair and host defense responses against influenza H1N1 virus and Staphylococcus aureus infections

Early studies indicated that vitamin D (VD) exerted pleiotropic extra-skeletal effects in the airway, but the definite linkage between VD deficiency and airway host responses remains unclear.

Shumin Liao, Yanhong Huang, **xiu Zhang, … in Respiratory Research (2023)

Article

Author Correction: Property space map** of Pseudomonas aeruginosa permeability to small molecules

Inga V. Leus, Jon W. Weeks, Vincent Bonifay, Yue Shen, Liang Yang… in Scientific Reports (2023)

Article

GSDME-dependent pyroptosis signaling pathway in diabetic nephropathy

Diabetic nephropathy (DN) is one of the serious chronic microvascular complications of diabetes, and leads to the increased morbidity and mortality in diabetic patients. Gasdermin E (GSDME)-dependent pyroptosi...

Shengyu Li, Lifeng Feng, Guangru Li, Ruiqing Liu, Changzhen Ma… in Cell Death Discovery (2023)

Article

Biomarkers of aging

Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...

Hainan Bao, Jiani Cao, Mengting Chen, Min Chen, Wei Chen… in Science China Life Sciences (2023)

Article

An induced annual modulation signature in COSINE-100 data by DAMA/LIBRA’s analysis method

The DAMA/LIBRA collaboration has reported the observation of an annual modulation in the event rate that has been attributed to dark matter interactions over the last two decades. However, even though tremendo...

Govinda Adhikari, Nelson Carlin, Jae** Choi, Seonho Choi… in Scientific Reports (2023)