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  1. Article

    Deletion of Ia-2 and/or Ia-2β in mice decreases insulin secretion by reducing the number of dense core vesicles

    Islet antigen 2 (IA-2) and IA-2β are dense core vesicle (DCV) transmembrane proteins and major autoantigens in type 1 diabetes. The present experiments were initiated to test the hypothesis that the knockout o...

    T. Cai, H. Hirai, G. Zhang, M. Zhang, N. Takahashi, H. Kasai, L. S. Satin… in Diabetologia (2011)

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  2. Article

    Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in mice

    We have previously reported that glucose-stimulated insulin secretion (GSIS) is induced by glucagon-like peptide-1 (GLP-1) in mice lacking ATP-sensitive K+ (KATP) channels (Kir6.2 ...

    W. Fujimoto, T. Miki, T. Ogura, M. Zhang, Y. Seino, L. S. Satin, H. Nakaya… in Diabetologia (2009)

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    Article

    Effects of intracellular calcium on GABAA receptors in mouse cortical neurons

     Using the patch-clamp technique, we studied the effect of intracellular Ca2+ on Cl– current gated by type A γ-aminobutyric acid receptors (GABAA) in mouse cortical neurons. When the rapid Ca2+ chelator 1,2-bis(2...

    L. G. Aguayo, F. Espinoza, G. Kunos, L. S. Satin in Pflügers Archiv (1998)

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    Article

    New mechanisms for sulfonylurea control of insulin secretion

    Oral antidiabetic sulfonylureas like tolbutamide and glyburide have been used to treat patients with noninsulin dependent diabetes mellitus. These agents lower blood glucose by stimulating insulin secretion fr...

    L. S. Satin in Endocrine (1996)

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    Article

    Calcium current inactivation in insulin-secreting cells is mediated by calcium influx and membrane depolarization

    Inactivation of voltage-dependent calcium currents was studied in single, dissociated insulin-secreting HIT cells voltage-clamped by the whole-cell patch-clamp method at room temperature. Na and K currents wer...

    L. S. Satin, D. L. Cook in Pflügers Archiv (1989)

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    Chapter

    Glucose Suppresses ATP-Inhibited K-Channels in Pancreatic β-Cells

    Glucose-induced insulin release involves a cascade of events in the pancreatic β-cell: the metabolism of glucose enhances the net uptake of calcium by the cell, mobilizes calcium from stores within the cell an...

    D. L. Cook, C. N. Hales, L. S. Satin in Biophysics of the Pancreatic β-Cell (1986)

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    Chapter

    Voltage-Gated Ca Current in Pancreatic Islet β -Cells

    Glucose induces rhythmic bursts of electrical spiking in mouse pancreatic islet β-cells.Several groups have shown that the spikes are dependent on extracellular Ca and are blocked by Ca channel blockers5,6.This e...

    L. S. Satin, D. L. Cook in Biophysics of the Pancreatic β-Cell (1986)

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    Article

    Voltage-gated Ca2+ current in pancreatic B-cells

    Voltage-dependent inward Ba++ and Ca++ currents were recorded in cultured neonatal rat pancreatic islet cells using the whole-cell voltage clamp technique. Outward current was suppressed by internal Cs+ and ATP a...

    L. S. Satin, D. L. Cook in Pflügers Archiv (1985)